植物甾醇微生物转化制备甾体药物中间体的研究进展_张裕卿.pdfVIP

D I牶牨牥牣牨牫牫牬牬牤j牣microbiol牣china牣牪牥牥牰牣牥牪牣牥牫牨 142 　　　　　　　　　　　　2006 33 (2) * 张裕卿　王东青 (　　300072) :-4--3, 17- (4-AD)-1, 4--3, 17- (ADD)。 , 、 , 。 :, , , : 629Q93　:A　:0253-2654 (2006)02-0142-05 Advances inM icrobialTransform ation ofPhytosterol into Steroid * M edicine Interm ediates ZHANG Yu-Qing　WANG Dong-Qing (S chool of Chem ica l Eng ineering and Techno logy, T ianjin Un iversity, Tianj in 300072) Ab stract:Microbial selective side-chain degradation of phytostero,l which can obtain the steroidmedicine inte-r mediate compounds -andros-t4-ene-3, 17-dione (4-AD)and androsta-1, 4-dien-e3, 17-dione (ADD), has an mi portantmeaning to pharmacy.There is no systematic literature concerned in existence. Its mechnism, ap- proaches, influencing factors and so on over these yearswere fully reviewed in the paper.The trend of develop- ment in the area is expanded. K ey words:Phytostero,l M icrobial transformation, Steroidmedicine intermediate,s Selective degradation , , , 。, 20 70 , , , 。 。, , 。 。 1　 ( 1), A /B, C /D, 4, * 　 (No.413395-0306) (No.411716) (No.033180811) 　Tel:022 022 E-mail:zhangguqing@tju.edu.cn :2005-07-21, :2005-08-30 　2006 33 (2)　　　　　　　　　　　　 143 4 Δ-3-。, C-17 , C-17, 。C-17, C-20, 24, 、 , C-17 。 C-17 C-17, -4--3, 17- (andros-t4-ene-3, 17-dione, 4-AD)-1, 4--3, 17- (androsta-1, 4- diene-3, 17-dione, ADD)( 2 )。 4-AD ADD , 。 20 60, Sih ADD。70, ADD。 20 80, ADD、 4-AD。 1　β- 2　4-AD ADD 、 、