脑细胞激活论-中国科学院科技论文预发布平台.PDF

脑细胞激活论 孙作东* （黑龙江省亚欧脑科学研究院 哈尔滨 150090） 摘要： 是一种基于经颅磁电刺激技术有效治疗帕金森病、阿尔茨海默病的新观点，可理解成电压门 控钙离子通道物理激活最佳靶点假说，基本内容：帕金森病、阿尔茨海默病等神经元退行性 变疾病，与物理门控离子通道密切相关，可用物理手段来解决，激活递质能神经元是治疗 的关键，电压门控钙离子通道则是物理手段激活的最佳靶点，目的是诱导钙离子内流触发 神经元轴突终末突触囊泡释放神经递质。脑细胞激活论，指出了阿尔茨海默病、帕金森病等 神经元退行性变疾病的治疗原则、方法与目的，提示了试图通过药物化学手段来寻求神经元 退行性变疾病的解决办法，可能会动摇我们应对疾病的信心，而物理手段的应用或物理化 学手段的联合应用也许是我们今后应对一些重大脑病的主要科研方向。 1 关键词：神经元退行性变；物理手段；经颅磁电；电压门控 Ca2+通道；最佳靶点 v 4 分类号：Q291 0 0 The theory of brain cell activation 0 0 Sun Zuodong* . 2 (Ya’ou Brain Science Institute of Heilongjiang province ，Harbin , 150090, 0 China) 7 1 0 Abstract： 2 This is a new idea that based on effective treatment of Parkinsons disease : v and Alzheimers disease with transcranial magnetoelectric stimulation i X technology, it can understand a hypothesis about voltage-gated Ca2+ channels is a the best target for activation by physical means, basic content ：Parkinsons n i disease , Alzheimers disease etc. neuronal degeneration diseases, that closely h related to physical-gated ion channels, which can be treated with physical c means, activating neurotransmitters-energic neurons plays key roles in the treatment, and voltage-gated Ca2+ channels is the best target for physical means, the purpose is to induce Ca2+ inflowing and triggers neuronal axon terminals synaptic vesicles releasing neurotransmitters. The theory of brain cell activation sets forth the principle, method and purpose of treatment of the physical