组织型纤溶酶原激活剂的非溶栓效应-中国卒中杂志.PDF

462 Chin J Stroke, May 2017, Vol 12, No.5 ·综述· 组织型纤溶酶原激活剂的非溶栓效应 左联，李刚 作者单位 【摘要】 研究显示组织型纤溶酶原激活剂（tissue plasminogen activator，tPA）除了发挥溶栓作用外， 200123 上海 还有一些非溶栓效应。目前认为tPA可以增加血脑屏障通透性和促进神经细胞死亡，发挥神经毒性 上海市东方医院（同济 作用。另一方面，基础和临床研究还显示tPA具有神经保护作用。此外，tPA对血管壁、血压都可能有 大学附属东方医院）神 正性或负性作用。对tPA溶栓作用外的病理生理作用的研究有助于其更好的临床应用。 经内科 【关键词】 组织型纤溶酶原激活剂；血脑屏障；血管；神经毒性；神经保护作用 通信作者 【DOI】 - 李刚 10.3969/j.issn.1673 5765.2017.05.019 ligang@tongji.edu.cn Non-thrombolytic Effect of Tissue Plasminogen Activator ZUO Lian, LI Gang. Department of Neurology, East Hospital Affiliated to Tongji University, Shanghai 200123, China Corresponding Author:LI Gang, E-mail:ligang@tongji.edu.cn 【 】 Abstract Some studies have showed non-thrombolytic effects of tissue plasminogen activator (tPA) more than thrombolysis. tPA was thought to exert neurotoxicity by increasing the permeability of blood-brain barrier and accelerating neuronal death. On the other hand, both fundamental and clinical studies have showed neuroprotective effects of tPA, and its positive/negative effects on blood vessel and blood pressure. Further research focusing on the pathophysiological mechnism of tPA other than thrombolysis is necessary for its more clinical application. 【 】 Key Words Tissue plasminogen activator; Blood-brain barrier; Blood vessel; Neurotoxicity; Neuroprotection 自1996年美国食品及药物管理局