趋化性细胞因子受体CXCR4与肺癌侵袭和转移的关系.pdfVIP

第 35 卷第 6 期第 801 页 华中科技大学学报(医学版) Vo l. 35 No.6 P. 801 2006 年 12 月 Acta Med Univ Sci Technol Huazhong Dec. 2006 ，，~-~-~-~-~、、 1 临床研究j 趋化性细胞因子受体 CXCR4 与 肺癌侵袭和转移的关系 5长孟贤 于世英A 夏曙 华中科技大学同济医学院附属同济医院肿瘤科，武汉 430030 摘要 目的 探讨趋化性细胞因子受体 CXCR4 在肺癌中的表达及其意义。方法 收集 72 例非小细胞肺癌患者子 术标本，用免疫组织化学方法检测肿瘤组织中 CXCR4 的表达和微血管密度，分析 CXCR4 的表达水平与临床病理特征 和预后的关系，12 例正常肺组织作为对照。结果 72 例非小细胞肺癌组织中，46 例 CXCR4 蛋白表达阳性，阳性率为 63.9% ;12 例正常肺组织中，仅 2 例 CXCR4 弱阳性表达，阳性率为 16.7% ，两者比较，差异有显著性意义(PO.O日。肺 CXCR4 阳性表达与 N 分期、微血管密度、复发/转移和生存时间密切相关(均 P0.05) 。结论 CXCR4 可能促 癌组织 进肺癌的侵袭、转移以及血管生成并影响其预后。 关键词 CXCR4 蛋白; 肺癌; 侵袭p 转移 中图法分类号 R734.2 Effect of Chemokine Receptor CXCR4 on the Invasion and Metastasis Capability in Lung Cancer Zhang Mengxian , Yu Shiying6 , Xia Shu Deρartment of Oncology , Tongji Hospital , Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 Ab唱tract Objective To investigate the expression of chemokine receptor CXCR4 in non-sma Il ce Il lung cancer (NSCLC) and the probable significance. Methods Tumor tissues were collected from 72 patients with NSCLC who underwent surgery from January 1996 to June 1998 at the Department of Surgery , Tongji Hospital. Twelve samples of normal lung tissues were co Ilected as controls during the same period. lmmunohistochemical study for detection of CXCR4 expression and microvessel density was performed. The expression levels of CXCR4 in tumor tissues and normal tissues were compared and the correlation between the expression levels of CXCR4 and clinicopathological factors was