脑肿瘤植物模型的研究停顿(国外英文资料).docVIP

脑肿瘤动物模型的研究进展(国外英文资料) Progress in the study of brain tumor models The animal model is the study of tumor pathogenesis and the powerful weapon testing various treatment methods, in this paper, the brain tumor animal models in the history of the development and application prospect. The keyword brain tumor animal models are transgenic Brain tumors is still is a serious threat to human health and the disease of life, and the establishment of the experimental animal model for studying the tumor pathogenesis, biology characteristics, and the detection of various treatment provides a high simulation tools. Since the last century, has established the chemical induced brain tumor model, viruses cause model, the same and xenograft model, with the development of modern molecular biology techniques, transgenic animal models and people will become the research hot spot. Early brain tumor model and its limitations An animal model of spontaneous brain tumor Incidence of brain tumors in mammals is differ, reports the dog is 0.1-0.5%, SD rats (7803) is 0.44%, but another group of 41000 SD rats found only in 38 cases of central nervous system tumors, more rare in primates, had 14000 anatomy of the rhesus monkeys and 1247 rhesus monkey body, did not find one brain tumor [1]. Due to the low incidence of the disease, the spontaneous tumor model is difficult to be used for clinical diagnosis, with the characteristics of the concealment of the spontaneous tumor and the shortness of life of the neoplasm. Chemical induced model Early use of methyl cholanthrene was injected into the rat brain to induce brain tumors, most of which were glioma and meningioma. In the 1970s, the use of a synthetic carcinogen, n-nitrocarbamide, and its derivative ethyl nitrourea (ENU), were carried out to induce experiments. Kostener [2] and other 50 ㎎ / ㎏ emu to conception, after 20 days of rats with disposable intravenous offspring appeared in the central nervous system tumors, but emu, in adult rat brain tumo