小儿牛黄清心散对热性惊厥后脑损伤保护作用的临床研究.pdf

湖 南 中 医 药 大 学 学 报 2017年 2 月第37卷第2 期 216 Journal of Hunan University of Chinese Medicine Feb . 2017 Vol . 37 *〇.2 本文引用:李冉.小儿牛黄清心散对热性惊厥后脑损伤保护作用的临床研究[J ].湖南中医药大学学报，2017,37(2):216-219. 小儿牛黄清心散对热性惊厥后脑损伤保护作用的 临床研究 李 再 (泰山医学院附属莱芜医院，莱芜市人民医院儿科，山 东 莱 芜 271100) 〔摘要〕 目 的探讨小儿牛黄清心散对热性惊厥后脑损伤的保护作用 。方 法将 7 4 例复杂性热性惊厥患儿随机分为治疗组 4 0 例和对照组 3 4 例 ，均予以常规治疗 ，治疗组加用小儿牛黄清心散口服 ，疗 程 14 d 。比较两组治疗前后血清神经元特异性烯醇化 酶 (NSE)水平及脑电图异常率 。结 果 治疗后治疗组血清 S E 水平恢复情况优于对照组 ( ！0.05);脑电图异常率也显著低于对照 组 ( ！0.05 )。结 论 小儿牛黄清心散治疗热性惊厥后脑损伤有明显疗效 ，且安全性良好 。 〔关键词〕热性惊厥 ；脑损伤 小儿牛黄清心散 ；神经元特异性烯醇化酶 〔中图分类号〕R272.3 〔文献标识码〕 B 〔文章编号〕d〇i:10.3969/j.issn.1674-070X.2017.02.027 Neuroprotective E ects of Xiaoer Niuhuang Qingxin Powder on Febrile Seizures Induced Brain Injury LI Ran (Department of Pediatrics, Laiwu Peoples Hospital, Laiwu Hospital Affiliated to Taishan Medical College, Laiwu, Shandong 271100, China) [Abstract] Objective To explore the neuroprotective effects of Xiaoer Niuhuang Qingxin powder on febrile seizures in­ duced brain injury. Methods Totally 74 patients with complex febrile seizures were randomly assigned into the treat­ ment group (40 cases) and the control group (34 cases). Both groups were treated with routine therapy, while the treat­ ment group was additionally given oral Xiaoer Niuhuang Qingxin powder, 14 d of one course. The serum neuron specific eno- lase (NSE) level and abnormal rate of electroencephalogram were compared before and after tr