自体骨髓干细胞移植治疗严重慢性下肢缺血性疾病15例.pdfVIP

中国组织工程研究与临床康复 多/2 fi Jlf 8 Jt1l 2∞8-02-19 出版 Joumal ofClinical Rehabilitative Tìssue Engineering Research Februaη /9， 2008 Vol.12, NO.8 @支在吏临床医学 自体骨髓干细胞移植治疗严重慢性下肢缺血性疾病15例食 甘字，郑长虹，湛静，贾鹏，郭贞臻，张继斌，李铁男，于黎丽 Autologous bone marrow stem cell transplantation for severe chronic lower limb ischemia in 15 cases Gan Yu , Zheng Chang-hong , Chen Jing , Jia Peng , Guo Zhen-zhen , Zhang Ji-bin , Li Tie-nan , Yu Li-li Abstract: Patients with severe chronic lower Iimb ischemia cannot receive bypass grafti吨， due to lack of g∞d outflow tract. Department of After autologous bone marrow stem cell transplantatio口， neovascularization and compensatory circulation were found in End田:rinology， Shenyang Sev回由 ischemic low limbs, which can improve blood supply. Totally 15 patients with severe chronic lower limb ischemia were People Hospi时， selected at the Department of Endocrinology of Seventh People Hospital from June 2006 to February 2∞7. There were rest Shenyang 11 创J03， p创n， ischemic ulcer and feet necrosis. The ankle-brachial index was from 萨0.5. Ambient artery obturated and Liaoning Provin晤， incommodious disease were proved by CTA or Color Doppler F10w lmaging (CDA). Patients singed the informed consents. China The experimental prlωedures were approved by hospital ethicaJ committee. Exclusive criteria: Having severe 句nction failure G皿吭 M田t町， in heart, lung or brain and failed to bear operation. Autologous bone m缸TOW was collected from double ilium, about 100- Associate chief 3∞mL bone marrow blood from each case, and separated by Hydroxyethyl and Ficoll. 50 mL mixture of stem cell with physician , 8