B130619_1708--PHMG降解谱图.pdf

1708 Bull. Korean Chem. Soc. 2013, Vol. 34, No. 6 Hyo Jin Hwang et al. /10.5012/bkcs.20708 MALDI-TOF Analysis of Polyhexamethylene Guanidine (PHMG) Oligomers Used as a Commercial Antibacterial Humidifier Disinfectant † ‡,* * Hyo Jin Hwang, Jungjoo Nam, Sung Ik Yang, Jung-Hwan Kwon, and Han Bin Oh * Department of Chemistry, Sogang University, Seoul 121-742, Korea. E-mail: hanbinoh@sogang.ac.kr †Department of Applied Chemistry, Kyung Hee University, Yongin, Gyeonggi 446-701, Korea ‡Division of Environmental Science and Ecological Engineering, Korea University, Seoul 136-713, Korea * E-mail: junghwankwon@korea.ac.kr Received February 27, 2013, Accepted March 14, 2013 Polyhexamethylene guanidine (PHMG) polymers used as an active ingredient in an antibacterial humidifier disinfectant were reported to cause harm to the human health when inhaled, although physical contact with this material was known to present low toxicity to humans. It is therefore necessary to develop an optimal analysis method which enables detection and analysis of PHMG polymers. MALDI-TOF investigations of PHMG are performed with a variety of matrices, and it is found that CHCA and 2,5-DHB are excellent matrices which well reflects the polymer population even at high mass. For the provided PHMG sample, the number-average (M )