P53、PS2在新辅助化疗中化疗敏感性的预测价值.pdf

CHINESECOMMUNITY DOCTORS 论著·临床辅助检查 P53、PS2在新辅助化疗中化疗敏感性的预测价值 1 1 2 张景臣(通讯作者) 刘薇 毛大华 450000郑州人民医院乳腺科1 550000贵阳医学院第一附属医院2 doi:10.3969/j.issn.1007-614x.2016.27.74 摘 要 目的：探讨P53、PS2在新辅助化疗中的化疗敏感性的预测价值。方法：对135例乳腺癌患者化疗前经空芯针 穿刺，经免疫组化确定P53、PS2表达情况。结果：4～6个周期的密集新辅助化疗后有完整化疗评价结果135例，化 疗总有效率76.3%；P53阳性79例、P53阴性56例，化疗有效率分别为81.01%、69.64%；PS2阳性65例、PS2阴性70 例，化疗有效率分别为72.31%、80.00%；P53、PS2表达情况与化疗疗效评价差异无统计学意义。结论：P53、PS2表 达与新辅助化疗敏感性无明显相关性，不能作为新辅助化疗疗效的敏感因子。 关键词 乳腺癌；P53、PS2表达；新辅助化疗；预测价值 PredictivevalueofsensitivityofPS2andP53inneoadjuvantchemotherapy 1 , 1 2 ZhangJingchen(Correspondingauthor) LiuWei,MaoDahua DepartmentofGalactophore,ZhengzhoupeoplesHospital4500001 TheFirstAffiliatedHospitalofGuiyangMedicalUniversity5500002 Abstract Objective:To evaluate the predictive value of the chemotherapy sensitivity of PS2 and P53 in neoadjuvant chemotherapy.Methods:The expression of P53 and PS2 in 135 patients with breast cancer before the chemotherapy were determinedbyhollowneedleaspiration,immunohistochemistry.Results:After4～6cyclesofintensiveneoadjuvantchemotherapy,a completeevaluationofchemotherapyresultsin 135cases,theoverallresponseratewas76.3%,79caseswerepositiveforP53,P53 negativein56cases,theeffectiverateofchemotherapywas81.01%,69.64%respectively;65caseswerepositiveforPS2andPS2 negativein70cases,theeffectiverateofchemotherapywas72.31%,80.00%respectively;P53andPS2expressionandevaluation ofcurativeeffectofchemotherapyhadnostatisticalsignificance.Conclusion:Therewasnosignificantcorrelationbetweenthe expression of P53 and PS2 and the sensitivity to neoadjuvant chemotherapy,which could not be used as a new adjuvant chemotherapyeffect. Keywords Mammarycancer;P53,PS2expression;Neoadjuvantchemotherapy;Predictivevalue