多孔聚合物微球的制备方法及表征.pdfVIP

中国医药工业杂志 Chinese Joumal of Pharmaceuticals 2015 , 46 (11) • 1245 • 多孔聚合物微球的制备方法及表征 乔红梅 (天津大学药物科学与技术学院，天津 300072) 摘要:多孔聚合物微球是一类具有较大比表面积和丰富孔结构的新型功能材料，具有制备方法多样、孔径可调控、表面 易修饰等诸多优点，目前在色谱填料、催化剂载体等领域应用广泛。本文综述了多孔聚合物的制备方法(悬浮聚合法、种 子溶胀法和微孔膜乳化法)及相应的成孔机制，并简要介绍了其性能表征及应用研究状况。 关键词:聚合物微球;制备方法:表征:应用:综述 中图分类号: R944.9 文献标志码:A 文章编号: 1001-8255 (2015) 11-1245-05 DOI: 10.16522/j.cnki功ph.2015.1 1.023 Preparation Methods and Characterization of Porous Polymer Microspheres QIAO Hongmei (School 01Pharmaceutical Science and Technology， 阳njin University， 阳njin 300072) ABSTRACT: Porous polymer microspheres are a kind of new functional material with larger specific surface area and plentiful pore structure. Because of the advantages of various preparation methods , controllable pore s住ucture and ease of modification , they have been widely used in the fields of chromatography colurnn packing and catalyst supports, etc. The preparation methods [suspension polymerization method, seed swelling pol归nerization method and membrane emulsification by Shirasu porous glass (SPG) membranes] and the corresponding pore forming mechanism are reviewed in this paper. And the characterization and applications ofporous pol归ner microspheres are also briefly introduced. Key Words: porous po阳ner microsphere; preparation method; characterization; application; review 多孔聚合物微球 (porous polymer microspheres) 种子溶胀法可制备单分散微孔、中孔聚合物微球， 且粒径可控[7J 。而微孔膜乳化法的提出为制备粒径、 是采用高分子合成手段制备的具有多孔结构的聚合 孔径均可控的多孔聚合物微球提供了技术支持 [8J 。 物球形颗粒。此类材料具有制备方法多样、易修饰、 孔径尺寸可调控等特点 [l] ，所以相关研究成为一大 本文介绍了各种制备技术及相应的成孔机制，并简 热点并且发展较快，目前己在色谱填料、催化剂载 要评述了其