乳酸菌肽聚糖研究进展.PDFVIP

微生物学通报 Jan. 20, 2016, 43(1): 188−197 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.150222 专论与综述 乳酸菌肽聚糖的研究进展 刘朝 乔建军 朱宏吉* (天津大学化工学院制药工程系 系统生物工程教育部重点实验室 天津 300072) 摘 要：肽聚糖是乳酸菌细胞壁的必需成分，它的化学结构较为保守固定，而其合成是一个涉及 多步反应的复杂过程。乳酸菌肽聚糖具有多种生物学活性，比如免疫增强功能、抗感染、抗肿瘤 及抗过敏等。本文对乳酸菌肽聚糖的组成结构和生物学活性进行了简要的介绍，重点综述了近年 来乳酸菌肽聚糖代谢及其调控过程的研究进展，并指出了乳酸菌肽聚糖未来研究的方向。 关键词：乳酸菌，肽聚糖，组成结构，代谢调控，生物学活性 Research progress in peptidoglycan of lactic acid bacteria * LIU Zhao QIAO Jian-Jun ZHU Hong-Ji (Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300072, China) Abstract: Peptidoglycan is an essential component of the cell wall of lactic acid bacteria, its chemical structure is mainly conservative and constant, and its biosynthesis is a complex process involving multi-step reactions. Peptidoglycan of lactic acid bacteria exhibits various biological activities, such as immune-enhancing functions, anti-infection, anti-tumor, and anti-anaphylaxis. In this review, the composition, structure and biological activity of peptidoglycan of lactic acid bacteria are outlined, the research development in metabolism and regulation of peptidoglycan is reviewed emphatically, and the direction to the future study of lactic acid bacteria peptidoglycan is proposed as well. Keywords: Lactic acid bacteria, Peptidoglycan,