氟西氟西汀经颅磁刺激 - 第三军医大学学报.doc

氟西汀联合经颅磁刺激治疗脑卒中后抑郁疗效研究 程素满1 陈金峰2 许萍1 （1开封市第五人民医院 河南省开封市， 475003，2开封大学化学工程学院 河南省开封市，475004） 【摘要】目的探讨临床疗效。方法将例抑郁患者随机分为和各例观察治疗6。于治疗前及治疗1、2 、4 、6 末采用汉密顿抑郁量表）(MESSS)进行神经功能康复评定，(MMSE)进行认知功能评定，改良Bar-thel指数(MBI)进行日常生活活动(ADL)能力评定。结果评分MESSS、MMSE和MBI评分显示：在治疗6周末，治疗组与对照组差异显著(P0.5)。结论起效更快。【关键词】；Therapeutic Effect of Fluoxetine Combined with Transcranial Magnetic Stimulation in The Treatment of Post-stroke Depression CHENG Su-Man1 CHEN Jin-Feng2 XU Ping1 1The Fifth People’s Hospital of Kaifeng City, Kaifeng , Henan, 475003, China ; 2College of Chemical Engineering Kaifeng University, Kaifeng, Henna, 475004, China [Abstract]Objectives: To study the therapeutic effect of Fluoxetine combined with transcranial magnetic stimulation in the treatment of post-stroke depression. Methods: 60 post-stroke depression patients were randomly assigned into treatment and control groups (each n=30)for 6 weeks．A-depression therapeutic effect, nervous functional impairment, cognitive function，the activities of daily living of the patients were assessed with the amilton Epression Scale(HAMD), MESSS, MMSE, and MBI respectively. Results: In the treatment group, the scores of the HAMD decreased significantly at the end of the 1st and 2st weeks (P0.05), the tolal scores of the MESSS, MMSE and MBI were obviously different at the end of 6th week compared with control group (P0.05). conclution: Fluoxetine Combined with Transcranial Magnetic Stimulation takes faster antidepressant effect, and can improve the nervous function and activity of daily living of patients with the post-stroke depression effectively. [Keywords]: Fluoxetine; transcranial magnetic stimulation; post-stroke depression 脑卒中后抑郁(Poststroke depression，PSD)是脑血管疾病常见的并发症之一(transcranial magnetic stimulation，TMS）是近年来兴起的神经电生理技术，对抑郁症、精神分裂症、强迫症、创伤后应激障碍和治疗慢性疼痛有效[1]，而将药物联合TMS应用于PSD的报道不多，文中就氟西汀联合经颅磁刺激治疗疗效来自20年月开封市第五人民医院的住院患者为研究对象。入组标准：(1) CT或MRI证实；(2)意识清楚，无失语及理解、表达障碍和严重智能损害；(3)无严重心、肝、肾病史及癫痫、青光眼和阳性精神病史；()符合《中国精神障碍分类与诊断标准》第3版(CCMD3)抑郁症诊断标准汉密顿抑郁量表