原发性肝癌患者血清AFP、AFU、CA199联合检测的临床意义.pdfVIP

透析与人工器官 2007年l2月(第l8卷)第4期 原发性肝癌患者血清AFP、AFU、 CA199联合检测的临床意义 毛莉萍，徐建中 【摘要】 目的 探讨原发性肝癌患者血清AFP、AFU、CA199含量及意义。方法 分别应用 放射免疫法和生化法对46例原发性肝癌患者血清AFP、AFU、CA199含量进行检测，并与42名肝 炎肝硬化患者和4O名正常人进行比较。结果 原发性肝癌患者血清AFP、AFU、CA199含量显著 高于肝炎肝硬化组及正常人组(P0．01)。AFP、AFU、CA199三项指标在原发性肝癌中的阳性率 分别为76．09％、71、74％、80．43％，AFP+AFU、AFP+CA199、AFP+AFU+CA199联合检测的阳性 率分别为89．13％、84．78％、95．65％。结论 联合检测血清AFP、AFU、CA199含量可以提高对原 发性肝癌的诊断阳性率。 【关键词】 原发性肝癌；甲胎蛋白(alpha fetoprotein，AFP)；a—L岩藻糖苷酶(slphs—L．fucosi dase，AFU)；糖类抗原一199(carbohydrate antigen 199．CA199) 中图分类号：R 735．7 文献标志码：A 文章编号：1005 0809(2007)04—0005—02 Clinical Significance of Detection Combined AFP，AFU and CA199 to Patients with Primary Liver Cancer MAO Li—ping，XU Jian—zhong (Nantong Third People’s Hospital，Nantong 226006，China) 【Abstract】 Objective To investigate the levels and clinical value of alpha—fetoprotein(AFP)，alpha-fueosi— dase(AFU)and carbohydrate antigen 199(CA199)in the patients with primary liver cancer．Methods Serum AFP，CA199 levels were measured with RIA and AFU levels were measured with biochemistry method in 46 patients with primary liver cancer，and compared with 42 patients with liver cirrhosis originating from chronic hepatitis 40 ， healthy people．Results The senlm AFP，AFU，CA1 99 levels were significantly hi er in the patients with primary liver cancer than patients with liver cirrhosis and healthy people(P0．01)．The positive rates of AFP，AFU and CA199 in patients with primary