75.小剂量他达拉非联合十一酸睾酮治疗功能性不射精.docVIP

小剂量他达拉非联合十一酸睾酮治疗功能性不射精 金保方1，2，3 ，张华俊1，叶 佳1，刘建国1，薛宇阳1，张新东1,2， 周玉春1,2 （1.南京中医药大学男科学研究所，江苏 南京，210046；2.南京中医药大学第三附属医院男科，江苏 南京，210001；3.江苏省人民医院临床生殖中心，江苏 南京，210036） 【摘要】目的：探索功能性不射精的有效治疗方法。方法：55例患者随机分为治疗组30例和对照组25例。治疗组他达拉非5mg，隔日一次，睡前1小时服用；十一酸睾酮，40mg，每日一次；结合性刺激，减少性交次数，戒除手淫。对照组给予麻黄素25 mg睡前口服。患者11例，无效5例总有效率为83.3%。对照组25例患者4例，，无效15例，总有效率40%。两组经χ检验，P0.05，统计学意义。Effect of Low dose Tadalafil and Testosterone Undecanoate in Treating Functional Anejaculation JIN Bao-fang1，2，3，ZHANG Hua-jun1，YE Jia1，LIU Jian-guo1，XUE Yu-yang1， ZHANG Xin-dong1，2，ZHOU Yu-chun1，2 1.Research Institute of Andrology, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210046; 2. Andrology,the Third Affiliated Hospital of NJUTCM, Nanjing, Jiangsu, 210001; 3.Jiangsu Province Hospital Center of Clinical Reproductive Medicine, Nanjing, Jiangsu, 210036 【Abstract】Objective: To observe the therapeutic effect of low dose tadalafil and testosterone undecanoate for treatment of functional anejaculation(AE). Methods: Fifty-five AE patients were randomized into the treated group (30 patients) treated with tadalafil, 5mg, once every other day, taking 1 hour before bedtime and testosterone undecanoate, 40mg, once daily and the control group (25 patients) treated orally with ephedrine 25 mg at bedtime. Meanwhile, they were told stimulation, reduce frequency of sexual intercourse, get rid of masturbation. The therapeutic course for both was one to three months. Results: The totaleffective rate was 83.34% (25/30) in the treated group, which was significantly higher than that in the controlgroup, 58.3% (10/25, P0.05). Conclusion: Low dose tadalafil and testosterone undecanoate for treatment of AE is safe and effective. 【Key Words】anejaculation; tadalafil; testosterone undecanoate; sex guide 功能性不射精症属临床疑难杂症，在男科门诊并不少见，大多因不能生育而就诊。病人性欲及阴茎勃起功能均正常，始终无性高潮或性快感，亦无射精，但平时有遗精，或手淫可射精。其病因及发病机理尚无定论，目前也无特效治疗方法。我们在临床上以小剂量他达拉非联合十一酸睾酮结合性生活指导，疗效显著，现总结如下。 1　资料与方法 1.1一般资料　55例患者来自南京中医药大学男科学研究所和江苏省人民医院生殖中心门诊，均因婚后不育而门诊。年龄21~30岁，平均