斑螯酸钠维生素B6联合PC方案对卵巢恶性肿瘤组织中血管内皮生长因子表达的影响.docVIP

斑螯酸钠维生素B6联合PC方案对卵巢恶性肿瘤组织中血管内皮生长因子表达的影响 摘要：目的 分析斑螯酸钠维生素B6联合PC方案对卵巢恶性肿瘤组织中血管内皮生长因子表达的影响 方法 选择2013年12月至2014年12月我院接诊的126例卵巢恶性肿瘤患者，将其随机分为观察组（63例）和对照组（63例），观察组患者采用斑螯酸钠维生素B6联合PC方案对患者进行治疗，对照组患者采用常规的化疗方式（PC方案）对患者进行治疗。对比分析两组患者的疗效、住院时间、卵巢恶性肿瘤组织中血管内皮生长因子（VEGF）的表达以及患者不良反应等。 结果 治疗后对照组患者的血清VEGF下降程度明显高于观察组，两组数据的差异对比存在统计学意义，（即P＝0.0003＜0.05)。观察组的不良反应总发生率低于对照组的不良反应总发生率，两组数据的差异对比存在统计学意义，（即P＝0.0024＜0.05)。观察组的治疗有效率高达85.71％明显高于对照组的治疗有效率50.80％，两组数据的差异对比存在统计学意义，（即P＝0.0000＜0.05)。结论 斑螯酸钠维生素B6联合PC方案对卵巢恶性肿瘤组织中血管内皮生长因子影响明显，疗效好，值得临床推广应用。 关键词：斑螯酸钠维生素B6；PC方案；卵巢恶性肿瘤；血管内皮生长因子；疗效 Effect of cantharidin sodium vitamin B6 combined with PC program for ovarian cancer tissue vascular endothelial growth factor expression Abstract：Objective To analyze cantharidin sodium vitamin B6 combined with PC program for ovarian cancer tissue vascular endothelial growth factor expressionMethods Choosing 126 cases of ovarian cancer patients from December 2013 to December 2014 in our hospital admissions was randomly divided into two groups: observation group (63 cases) and control group (63 cases). The observation group was treated with vitamin B6 sodium cantharidin joint PC program for treatment of patients and the control group was treated with conventional chemotherapy manner (PC program). Comparison of the efficacy, hospital stay, ovarian cancer tissue vascular endothelial growth factor (VEGF) expression and adverse reactions of two groups’ patients. Results After treated, the decreased degree of patients’ serum VEGF of the observation group was significantly higher than that of patients of the control group. Comparing the difference of two groups’ data was statistically significant (i.e. P = 0.0003 0.05). The incidence of adverse reactions in the observation group was lower than the incidence of adverse events in the control group. The difference between two groups of figures was statistically significant (i.e. P = 0.0024 0.05). The efficiency (85.71%)of the treatment in the observation group was significantly highe