益生菌对溃疡性结肠炎患者肠黏膜屏障的修复作用.pdfVIP

现代消化及介入诊疗 2007年 第l2卷 第4期 Modem DigestionIntervention 2007，Vo1．12，No．4 — — 225—— · 论 著· 益生菌对溃疡性结肠炎患者肠黏膜屏障的 修复作用 张智翔 施炳龙 关幸求 杨莉丽 邹 兵 【摘要】目的探讨益生菌对溃疡性结肠炎患者肠黏膜屏障的修复作用。方法将54例溃疡性结肠炎 患者随机分为研究组和对照组。观察双歧杆菌、乳杆菌、嗜热链球菌治疗前l天、治疗后l4天患者乳果 糖、甘露醇尿液排泄率比值(LAC／MAN)以及血浆内毒素水平。结果 益生菌治疗后患者肠黏膜通透l生显 著下降(P0．01)，血浆内毒素水平也明显下降(P0．05)。结论 益生菌可能对溃疡性结肠炎患者肠黏膜 屏障有一定修复作用 【关键词】益生菌；肠黏膜屏障；溃疡性结肠炎 The reparation of intestinal mucosal barrier of patient with ulcerative colitis by probiotics ZHANG Zhi— xiang，SHI Bing—long，GUAN Xing—qiu，et a1．Department ofdigestive disease，Be ng University Shenzhen Hospita1．Shenzhen《518036)，China 【Abstract】Objective To observe the influence of bifidobacterium，lactobacillus and streptococcus me卜 mophilus on the reparation of intestinal mucosal barrier of patient with ulcerative colitis．Methods A prospec- tive，randomized and controlled trial was taken．Fifty—four patients with ulcerative colitis were divided into 2 groups：control group and study group．The patients in study group were treated with bifidobacterium，lacto- bacillus and Streptococcus．Th e intestinal mucosal permeability and plasma endotoxin on 1st day before treat- ment and 14th day after treatment were measured．Results Th e intestinal mucosal perm eability and plasma en—— dotoxin of patients with ulcerative colitis degraded after treatment by probiotics． Conclusion Th e intestinal mucosal barrier of patients with ulcerative colitis could be repaired by probiotics． 【Key words】Probiotics；Mucosal barrier of intestine；Ulcerative colitis 溃疡性结肠炎(ulcerative colitis，UC)的发病机 56岁，平均年龄38．7岁；病程10～36月，平均病程 制仍未明确，一般认为它是基因易感性、肠道细菌及 16．8月；对照组(UC2)：27人，其中男性20人，女性 自身免疫反应协同作用的结果。当前治疗仍以糖皮 7人；年龄20～58岁，平均年龄38．3岁；病程12～ 质激素类、氨基水杨酸类和免疫抑制剂等药物为主。 36月，平均病程17．5月。研究组患者