慢性萎缩性胃炎患者IL-10、IL-12的表达水平及其临床意义.pdfVIP

第28卷 第4期 青 海 医 学 院 学 报 V01．28 No．4 2o07年 JOURNAL OF QINGHAI MEDICAL COLLEGE 2007 慢性萎缩性胃炎患者IL一1 O、 IL一1 2的表达水平及其临床意义 张洪芳 范钟麟 王学红 (1．青海大学医学院；2．青海大学附属医院消化内科) 摘 要 目的 探讨IL一10、IL一12在慢性萎缩性胃炎(CAG)中的表达及意义。方法 用双 抗体夹心ELISA法检测30例CAG患者胃粘膜上清液中lL一10、IL一12的含量，同时以10例健康 人检查结果为对照进行比较分析。结果 轻度CAG患者胃粘膜上清液中IL一10、IL一12的含量 无明显变化；重度CAG患者胃粘膜上清液中IL一10的含量明显高于健康人及轻度CAG患者(P 0．01)，而IL一12的含量则明显降低(P0、01)。同时，重度CAG患者的IL一10浓度与IL一12浓 度呈显著负相关(r=一0．786，P0．01)。结论 重度CAG患者胃粘膜免疫细胞因子表达水平异 常。 关键词 慢性萎缩性胃炎 癌前病变 白细胞介素一10 白细胞介素一12 中图分类号 R735．2 文献标识码 A THE CONCENTRATION OF IL—l0 AND IL—l2 IN THE PATIENTS WITH CHRONIC ATROPHIC GASTRITIS AND THEIR CLINICAL SIGNIFICANCE Zhang Hongfong ， Fan Zhongling 。 Wang Xuehong (1．Qinghai University Medical College； 2．Qinghai University Affiliated Hospital department of digestive internal medicine) Abstract Objective To study interleukin(IL)一1 0 and IL一1 2 level in patients with chronic atrophic gas— tritis(CAG)and their clinical significance．Methods Using ELISA assay，the contents of IL一10 and IL一12 in nmcosa of patients with CAG were examined and compared with that of 10 healthy adults．Results There was no significant change in contents of IL一10 and IL一12 in gastric mucosa of 15 patients with mild CAG．However，in patients with severe CAG，the contents of IL一1 0 in gastric mucosa was significantly higher(P0．O 1)，while the contents of IL一12 was obviously lower(P0．01)as compared respectively with those in healthy adults or pa— tients with mild CAG．．In addition，it was found that there was a significant negative correlation between the con— tents of IL一10 and IL一12 in patients with severe CAG(r=一0．786，P0．01)