LKB1、AMPK及mTOR在喉鳞状细胞癌中的表达及临 床意义.pdfVIP

目 录 中文摘要···································································································1 英文摘要··········································································································4 英文缩写··································································································8 研究论文LKB1 、AMPK 及mTOR 在喉鳞状细胞癌中的表达及临床意义 前言··········································································································9 材料与方法······················································································10 结果····························································································14 附图·······················································································16 附表·······················································································19 讨论·········································································································26 结论·······················································································32 参考文献····················································································33 综述 LKB1 、AMPK及mTOR 与恶性肿瘤··········································38 致谢··················································································································53 个人简历····································································································54 万方数据 中 文 摘 要 LKB1 、AMPK 及mTOR 在喉鳞状细胞癌中的表达及临床意义 摘 要 目的: 探讨LKB1 、AMPK 及mTOR 在人喉鳞状细胞癌中的表达情况， 并分析三者的相关性及与人喉鳞状细胞癌临床病理因素的关系，探讨三者 在喉鳞状细胞癌的发生、发展中的作用机制及其相互作用关系，从而为喉 鳞状细胞癌的早期诊断、靶向治疗提供理论依据。 方法: 选取河北医科大学第二医院耳鼻咽喉科经手术切除 42 例喉鳞 状细胞