杨一鸿教授-Perfusion Based Resting-State fMRI.ppt

? Perfusion-based rs-fMRI have the potential to study the static and dynamic characteristics of resting-state signals under a single modality within the same subjects. Static and Dynamic Characteristics of Perfusion signal in the Resting State * Perfusion Based Resting-State fMRI Yihong Yang, Ph.D. Introduction ? Spontaneous fluctuations in resting- state fMRI are significantly correlated in brain regions involved in specific networks. ? “Functional connectivity” of these brain regions can be revealed by resting-state fMRI. 50 100 150 200 250 300 350 640 0 690 680 670 660 650 time (sec) R L Seed Left primary motor Right primary motor Task-Induced Activation vs. Resting-State Functional Connectivity Biswal et al., MRM, 1995 Task Rest “Default Mode” of the Brain ? At rest, a set of brain regions (PCC, MPFC, insula, and thalamus) exhibit higher blood flow (CBF) and oxygen consumption (CMRO2) than the whole brain average. ? CBF in these regions decreases from its baseline level during goal-directed tasks (default mode). CBF CMRO2 Raichle et al., PNAS, 2001 19 95 19 96 19 97 19 98 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 20 08 20 09 0 100 200 300 400 500 600 700 800 Publications of “Functional Connectivity” PubMed search on “brain functional connectivity” Techniques to Measure Functional Connectivity: BOLD, CBF, and CMRO2 ?BOLD has been used for most of rs-fMRI studies, due to its high sensitivity and easy implementation. ?CBF has the advantage to quantify the baseline (static) and alteration (dynamics) of neuronal activity. ?CMRO2 (cerebral metabolic rate of oxygen) measures the metabolism associated with neuronal activity, and is independent from hemodynamics. Neuronal Activation and fMRI Techniques Modified from Bonvento, Sibson Pellerin, Trends in Neurosciences, CMRO2-MRI BOLD-MRI CBF-MRI CBV-MRI fMRI signal (S) CBF imaging Oxy-hemoglobin Deoxy-hemoglobin BOLD imaging R