诺和力早期应用的益处46.pptVIP

诺和力?可降低收缩压达6.7mmHg Marre et al. Diabet Med 2009;26;268–78 (LEAD-1); Nauck et al. Diabetes Care 2009;32;84–90 (LEAD-2); Garber et al. Lancet 2009;373:473–81 (LEAD-3); Zinman et al. Diabetes Care 2009;32:1224–30 (LEAD-4); Russell-Jones et al. Diabetologia 2009;52:2046–55 (LEAD-5); Buse et al. Lancet 2009;374:39–47 (LEAD-6) SBP变化(mmHg) 联合SU LEAD-1 联合Met LEAD-2 联合 Met + TZD LEAD-4 联合 Met + SU LEAD-5 单药治疗 LEAD-3 1 -5 -6 -7 -4 -3 -2 -1 0 -0.7 -2.8* 0.4 -2.6 -2.8 -6.7 -5.6 -4.0* 0.5 -0.9 -2.3* -2.1 -3.6* *** ** -2.5 -2.0 联合 Met 和/或 SU LEAD-6  -1.1 全部患者。 ***p0.0001 **p0.001 *p0.05 ，与基线相比。 安慰剂