参芪扶正注射液减轻肺癌化疗后副反应的临床视察.pdfVIP

提 要 目的：观察参芪扶正注射液减轻肺癌化疗后副反应的临床疗效。方法：将纳入标 准的40例患者随机分成两组，观察组20例，对照组20例。对照组单纯使用EP方案 化疗；观察组在 EP 方案化疗的基础上加用参芪扶正注射液，所有病例均观察 3 个周 期，21 天为一个周期。观察 3 个周期后观察组与对照组临床症状和化验室检查指标 的变化，其中以外周血细胞计数、肾功能、体重测定、KPS评分、中医症状为主要观 察指标。结果：治疗前观察组与对照组无差异，经治疗3周期后，观察组总卡氏评分、 临床症状缓解情况优于对照组，差异有显著性 (P0.05 或 P0.01),随着化疗时间及 化疗药物剂量的累积，观察组与对照组均出现外周血细胞计数降低、体重下降、肾功 能损害，但观察组外周血细胞计数、体重改变率、尿素氮数值与对照组有显著差异 （PO.O5），观察组与对照组肌酐数值比较无显著差异（PO.O5）。结论：参芪扶正注 射液能减轻化疗引起的体重下降、食欲减退、恶心呕吐等症状,对其所致骨髓抑制有 保护作用，在一定程度上减轻对肾功能的损害，提高患者的生活质量。 关键词 参芪扶正注射液；肺癌；化疗；副反应 Clinical Study on Reduced The Side Effects Of Chemotherapy Of Lung Cancer Treated by The Injection Of Shen Qi Fu Zheng Specialty：Intergrated Traditional and Western Internal Medicine Author ：Yin Xi Tutor ：Prof.Chen Zetao Abstract Objective：To observe the Shenqifuzheng injection to improve the Chemotherapy secondary reactions caused by the clinical efficacy. Methods ：It will be incorporated into the standard 40 patients were randomly divided into two groups to observe the group of 20 patients in control group 20 cases. Control group, the use of conventional chemotherapy alone; Observer Group on the basis of conventional chemotherapy was added injection of Shen qifuzheng, All cases were observed in three cycles, 21 days for a cycle. Observed after three cycles and control groups of clinical symptoms and laboratory indicators of changes in check, of which the main observation of indicators of Chinese medical symptoms,the week of blood count,Kidney function,KPS score and Weight.Results: observation group and control groups are non-difference at the beginning. After treatment for 3 cycles, the observation group and control group suffered from Chemotherapy secondary reactions.