adipophilin 介导脂质蓄积及炎症反应的研究进展 - 中国动脉硬化杂志.pdf

472 ISSN 1007鄄3949 Chin J Arterioscler,Vol21,No5,2013 ·文献综述 · [文章编号]摇 1007鄄3949(2013)21鄄05鄄0472鄄05 Adipophilin介导脂质蓄积及炎症反应的研究进展 陶媛,郭东铭摇 综述,袁中华摇 审校 (南华大学心血管病研究所 动脉硬化学湖南省重点实验室,湖南省衡阳市421001) [关键词]摇 Adipophilin;摇 脂滴;摇 脂质蓄积;摇 炎症反应;摇 动脉粥样硬化 [摘摇 要]摇 脂质蓄积与炎症反应在动脉粥样硬化中发挥关键作用,两者相互促进,相互影响。 而Adipophilin作为 胞浆脂滴的一种不完全包被蛋白,不仅可以作为动脉粥样硬化脂质蓄积的一种标记物,而且能够促进脂质蓄积、抑 制细胞内胆固醇外流,并介导TNF鄄琢、MCP鄄1和IL鄄6等炎症介质分泌,其表达受核受体、脂肪酸、修饰脂蛋白、激素 类物质等多种因素的调控。 本文就Adipophilin在脂质蓄积与炎性反应中的作用及其调控做一简要综述,为通过调 控Adipophilina 防治动脉粥样硬化提供新的思路。 [中图分类号]摇 R363 [文献标识码]摇 A Adipophilin MediatedLipidAccumulation andInflammation Reaction ResearchPro鄄 gress TAOYuan,GUO Dong鄄Ming,and YUAN Zhong鄄Hua (Institute of Cardiovascular Disease, Key Laboratory of Arteriosclerosis of Hunan Province, University of South China, Hengyang,Hunan421001,China) [KEY WORDS]摇 Adipophilin;摇 Lipid Droplets;摇 Lipid Accumulation;摇 Inflammation Reaction;摇 Atherosclerosis [ABSTRACT]摇 Lipid accumulation and inflammatory reaction play a key role in the process of atherosclerosis,which promote and influence each other. The Adipophilin as cytoplasmic lipid droplets of imperfect鄄coating protein,not only can be usedasamarkerof atheroscleroticlipidaccumulation,butalsocanpromotelipidaccumulation,andinhibittheeffluxof intracellular cholesterol,and mediatethesecretionof someinflammatorymediators,suchasTNF鄄琢,MCP鄄1andIL鄄6,and its expression is regulated by variousfactors,like the nuclear receptors,fatty acid,modified lipoprotein and hormone鄄like substance. The purpose of thispaper istomakeanoverview of how Adipophilinaplaysaroleinlipidaccumulationandin鄄 flammatory response in order to help find a new thought about preventing Atherosclerosis through regulating. 摇 摇 动