18-羟皮质醇测定在原发性醛固酮增多症鉴别诊断中的意义（Determination of 18 - hydroxycortisol in the differential diagnosis of primary aldosteronism）.docVIP

18-羟皮质醇测定在原发性醛固酮增多症鉴别诊断中的意义（Determination of 18 - hydroxycortisol in the differential diagnosis of primary aldosteronism） Determination of 18 - hydroxycortisol in the differential diagnosis of primary aldosteronism 2011-09-05-09 liu libin ding wei mi zhi all hu renming luo bang-yao hui Chen jia lun [abstract] objective: to investigate the value of 18 - hydroxyl cortisol in the differential diagnosis of primary aldosterone (prodosterone). Competitive avidin biotin - methods enzyme-linked immunosorbent assay to detect the original aldehyde 36 cases, including 26 cases of adenoma and 10 cases of idiopathic hyperplasia), 22 cases of other adrenal disease, in addition to the original aldehyde secondary aldosteronism 6 cases, 25 cases of primary hypertension and 21 normal blood, urine, 18 - hydroxyl cortisol levels and comparison, at the same time is part of the original aldehyde, 18 - hydroxyl cortisol adenoma patients with change. The results of the original aldehyde adenoma patients, 18 - hydroxyl cortisol levels are significantly higher than other groups, including the original aldehyde hyperplasia patients (P 0.05), and other 18 - hydroxyl cortisol levels between groups have no obvious difference (P 0.05), the original aldehyde adenoma, 18 - hydroxyl postoperative cortisol levels significantly lower than the preoperative (P 0.05). Conclusion 18 - hydroxyl cortisol is a sensitive and specific index in the differential diagnosis of aldol. [key words] 18 - hydroxycortisol, primary aldosteronism Significance of the diagnosis of primary aldosteronism LIU Libin, DING Wei, MI Zhijun, et al. Rui Jin Hospital, affiliated to Shanghai Second Medical University, Shanghai Institute of Endocrinology, Shanghai, 200025 【Abstract】　Objective　To study the clinical value of 18-hydroxycortisol assay in the differential diagnosis of primary aldosteronism. Methods　The levels of blood and urine 18-hydroxycortisol in 26 cases of aldosterone-producing adenoma (APA), 10 cases of idiopathic