免疫网络（Immune network）.docVIP

免疫网络（Immune network） The theory of immune network is a theory proposed by N.K. (1972) on the basis of the clonal selection theory of F.M. Burnett. Later, Richter, Hoffman and Toda were supplemented. Network (immunologic) a chain of self identification in the body. The variable region of antibody not only shows antibody activity, but also has antigen activity because of its unique antigenic determinant. Antibody can recognize antigen, but also by other cell clone identification, resulting in anti idiotype antibodies. Both the free antibody molecule and the immunoglobulin receptor of the lymphocyte membrane show a specific idiotype. According to the clonal selection theory, cell clones that recognize antigens have been identified before antigen enters the body, as well as cell clones that recognize the cells unique phenotype. After antigen enters the body, the cell clone that identifies this antigen is activated, produce a large number of antibody element. Its unique type also activated second cell clones, activated second cell clones, and then activated third cells. When the body to produce antibodies to foreign antigens Ab-1, the body can produce antibodies against Ab-1 Ab-2 unique type, and then have Ab3 for Ab2 idiotypic antibody. These in turn produce antibody anti idiotypic antibodies and other special type cross reaction, thus forming a complex network of in vivo. The theory of immune network can explain the generation of immune response and tolerance. For example, a low dose of antigen stimulates the organism to produce Ab - 1, which then produces Ab - 2. Because Ab 2 has an inhibitory effect on Ab 1, the production of Ab 1 is inhibited, which is a low dose of immune tolerance. If the antigen dose is slightly larger and can produce Ab - 3, then the Ab - 3 inhibits the idiotype of Ab - 2, resulting in the normal release of Ab-1, which results in a humoral immune response. If the antigen dose is larger, it can also produce Ab - 4, then Ab-3 is inhibited and Ab-2