补肾中药提高LPD患者子宫内膜LIF表达的探究.pdfVIP

提 要 目的：观察补肾中药二至天癸颗粒对黄体功能不健性不孕症子宫内膜容受性的影 响并探讨其作用机理。方法：将 60 例黄体功能不健性不孕症患者随机分为二至天癸 颗粒联合西药组（试验组，30 例）和六味地黄颗粒联合西药组（对照组，30 例），观 察治疗前后中医证候改善情况，黄体中期血清雌二醇（E2 ）、孕酮（P ）水平，黄体中 期子宫内膜 LIF 表达，及两组患者的妊娠率。结果：（1）试验组患者临床肾虚症状得 到有效改善，与对照组比较差异有显著性（P0.05 ）。（2 ）试验组服药后黄体中期血 清 P 水平明显高于对照组，差异有显著性（P0.05 ）；两组患者服药后黄体中期血清 E2 水平均较服药前升高，但差异无显著性（P 0.05 ）。（3 ）试验组服药后黄体中期子 宫内膜 LIF 表达量明显高于对照组，差异有显著性（P0.05 ）。（4 ）试验组妊娠率与 对照组比较，试验组高于对照组，差异有显著性（P 0.05 ）。结论：二至天癸颗粒治 疗黄体功能不健性不孕症可能与提高其子宫内膜容受性有关，其机理可能与提高子宫 内膜LIF的表达有关。 关键词 补肾中药；黄体功能不健；子宫内膜容受性；白血病抑制因子 Studies on tonifying kidney herb in improving the expression of LIF on luteal metaphases endometrium of luteal phase defect sterility women Speciality: Gynecology of TCM Author: He Ruiyan Tutor: Pof. Lian Fang Abstract Objective: to study the effect of Tonifying kidney herb Erzhitiangui(EZHTG) decoction to the endometrial receptivity of luteal phase defect sterility women ，and explore its acting mechanism. Methods: 60 patients of luteal phase defect sterility women were randomly divided into the tested group (treated with EZHTG decoction combined with western medicine) and the control group (treated with Liuweidihuang decoction combined with western medicine), and were observed on improvement of symptoms of TCM before and after treatment and detected serum estradiol and progestone level on the day of luteal metaphase before and after treatment. We also compared the expression of LIF in luteal metaphases endometrium after treatment and the pregnancy rate between the two groups.Results: (1) the tested group was obviously better than the control group in improving the insufficiency of kidney ( P0.05). (2) After the treatment the serum progestone level on t