解毒活血汤联合甲氨蝶呤治疗老年发病类风湿关节炎的临床探究.pdfVIP

提 要 目的：观察解毒活血汤联合甲氨蝶呤治疗老年发病类风湿关节炎的临床疗效，探 讨老年发病类风湿关节炎的中医病因病机及治则治法，为该病的治疗提供新的思路和 方法。方法：将 50 例入选的老年发病类风湿关节炎患者随机分为治疗组（25 例）， 对照组（25例），治疗组采用解毒活血汤联合甲氨蝶呤治疗，对照组采用甲氨蝶呤治 疗，疗程为3个月，采用美国风湿病学会制定的ACR标准作为疾病疗效观察标准。结 果：临床观察显示，疗程结束时，治疗组达到 ACR70 标准 1 例，达到 ACR50 标准 9 例，达到ACR20标准13例，总有效率92.00%，对照组无达到ACR70标准病例，达到 ACR50标准2例，达到ACR20标准14例，总有效率64.00%，治疗组优于对照组（P0.05）。 在改善主要症状、体征及实验室检查指标等方面均优于对照组（P0.05）。结论：解 毒活血汤联合小剂量甲氨蝶呤是老年发病类风湿关节炎的有效疗法，具有改善患者的 临床症状体征，降低血沉（ESR）及C反应蛋白（CRP），缓解病情等作用。 关键词 老年发病类风湿关节炎；解毒活血汤；临床研究 Clinical Study on Jieduhuoxuetang united Methotrexate in treating of Elderly-onset Rheumatoid Arthritis Speciality: Internal Medicine of TCM Rheumatic Disease Author: Jia Dongmei Tutor: Prof. Fu Xinli Abstract Objective: To observe the Jieduhuoxuetang united Methotrexate treatment of Elderly- onset rheumatoid arthritis clinical efficacy. To explore the Elderly-onset rheumatoid arthritis TCM Etiology, Pathogenesis and new treatment. Methods: 50 selected patients with Elderly-onset rheumatoid arthritis were randomly divided into treatment group (25 cases), the control group (25 cases), patients in the treatment group were administered with Jieduhuoxuetang United Methotrexate, while those in the control group treated with Methotrexate.Total therapeutic course was 3 monthes, using the United States Institute of Rheumatology issued by the ACR criteria to evaluate the effieacy. Results: The clinical observation showed that at the end of the stady ，the treatment group has 1 case achieved ACR70 criteria ，9 cases of the ACR50 criteria, and ACR20 criteria reached 13 cases, the control group have 2 cases of A