罗格列酮联合胰岛素治疗老年2型糖尿病的临床研究.pdfVIP

蛇 志 Journal of SNAKE(Science＆NAture are KEy to health) 2008年第2O卷第2期 Vo1．20 No．2，2008 罗格列酮联合胰岛素治疗老年2型糖尿病的临床研究 李金荣，蓝 海，覃丽娜，莫燕燕，李睿懿 (广西南宁市津头医院，广西南宁 530021) [摘要] 目的 观察罗格列酮联合胰岛素治疗老年2型糖尿病的疗效及安全性． 方法 将6O例老年2型糖尿病患者随机分 为治疗组和对照组各3O例，治疗组用罗格列酮4mg／d，同时加用胰岛索，两组均随访12周，观测血糖、胰岛索用量指标变化及药 物的不良反应f对照组单用胰岛素治疗并根据病情调整用量． 结果 治疗组血糖水平从第2周开始明显下降，第8～12周血 糖水平降幅最大，有21例达到空腹血糖6．5 mmol／L，餐后2 h血糖8．0 mmol／L的良好控制水平；从第 2周开始，治疗组胰 岛素用量也逐渐减少，至12周时，治疗组胰岛素用量较基础值减少(7．6士4．3)u；而对照组胰岛素用量却平均增加(9．1士5．1)u。 治疗后两组血糖和胰岛素用量比较差异有统计学意义(PO．05)． 结论 罗格列酮联合胰岛素治疗老年 2型糖尿病能有效 控制患者的血糖水平，且安全，无不良反应。 [关键词] 罗格列酮；胰岛素；2型糖尿病 [中国分类号] R587．1 [文献标识码] A [文章编号] 1001—5639(2008)02—0113—02 Clinical Study on Rosiglitazone combined with Insulin in the Treatment of Aged Type 2 Diabetes Mellitus LI Jin-rong，LAN Hai，QIN Li—na，MO Yan—yan，LI Rui—yi (Nanning Jintou Hospital，Nanning，Guangxi，530021，China) Abstract： Objective To observe the curative effect and the safety of combined with in the treatment of aged． Methods 60 cases of aged were divided randomly into two groups：the treatment group and the control group，with 30 cases each group．In the treatment group，(4 mg／d)was used with．The patients were followed up for 12 weeks．The blood glucose，the change of and of were observed．In the control group，was only used and the dosage was adjusted according to disease status． Results In the treatment group the blood glucose level began to decrease obviously from the 2 week and the decreasing range of blood glucose reached the maximum in the 8 to 12 week．21 cases achieved the goal of good control(6．5 mmol／L，postprandial 2 h blood glucose8．0 mmol／L)．From the 2 week the dosage of in the treatment group was reduced gradually．Until the 12 week the dosage of the treatment g