医院感染常见病原菌耐药性研究.docVIP

医院感染常见病原菌耐药性研究【摘要】 目的了解医院常见病原菌分布及耐药状况。方法 2009年1~5月期间,我院临床感染性标本中病原菌的分布及耐药率进行回顾性分析。结果 所分离的病原菌对抗菌药物均产生了较严重的耐药性,耐药率高的抗菌药物有:头孢曲松钠(94?1%),环丙沙星(91?8%),苯唑青霉素(87?0%),头孢他啶、头孢吡肟、氨曲南、复方新诺明、红霉素、(均50?0%)。敏感率较高的抗菌药物为:万古霉素(I 1?9%)、利奈唑胺(3?0%)、亚胺培南(4?0%)。结论 为防止医院感染,减少ESBLs菌株的产生,控制耐药菌株的播散和流行,临床需严格控制第三代头孢菌素及其他广谱β?内酰胺类抗菌药物的使用,做到合理应用抗菌药物。? 【关键词】 病原菌;耐药性;分析 Analysis of Drug Resistance of Common Nosocomial Infection Pathogens LIU Wei,LENG Ying?rong,LUO Guang?ying,et al. Affiliated hospital of Guiyang medical college,guizhou 550004,China ? 【Abstract】 Objective To know the etiology and drug resistance of common nosocomial infection pathogens? Methods The hospital carried out retrospective analysis on etiology and drug resistance of pathogens in clinical infectious sample from January to May 2009? ResultsPathogens separated have all produced serious drug resistance to antibacterial agents? Agents with relatively higher drug resistance rate include: ceftriaxone sodium(94?1%), ciprofloxacin(91?8%), oxacillin(87?0%), ceftazidime, cefepime, aztreonam,SMZ?TMP and erythrocin (all50%)? Agents with relatively higher susceptibility rate inculde: vancomycin (11?9%), linezolid (3?0%) and imipenem (4?0%)?Conclusion In order to prevent nosocomial infection, reduce ESBLs bacterial strain and take effective measures to contorl the prevalence of bacterial strain with drug?resistance, third?generation cephalosporins and other extended?spectrum β?lactamases (ESBLs) shall be used in clinical application in strict control realize more rationally use of antimicrobial drugs?? 【Key words】 Pathogens; Drug Resistance; Analysis ? 随着抗菌药物,免疫抑制剂的广泛应用,医院感染性疾病中病原菌的分布近几年呈上升趋势??[1]?,耐药菌感染引起的医院感染也逐渐增多,有暴发流行的报道??[2]?。为指导临床合理用药,延缓耐药菌株的产生,我们将2009年1~5月分离的菌株及耐药情况进行总结分析,现结果报告如下。? 1 资料与方法? 1?1 菌株来源 2009年1~5月,我院临床科室送检的感染性标本(痰液、脓液、尿液、血液、伤口分泌物、胸水、腹水等)? ? 作者单位:550004 贵州贵阳医学院附属医院? 中共分离阳性菌990株。? 1?2 细菌分离鉴定及药敏试验 遵照《全国临床检验操作规程》进行操作,根据细菌培养、染色、生化等特性进行鉴定。采用全自动培养,鉴定、药敏试验仪Microscan 40测定,购自美国德