原发性干燥综合征临床首发症状及实验室检查100例研究.docVIP

原发性干燥综合征临床首发症状及实验室检查100例研究【摘要】 目的 了解原发性干燥综合征(pSS)的临床首发症状及实验室检查的特点,提高对pSS的认识水平,以减少误诊漏诊。方法 对100例pSS的临床资料进行回顾性分析。结果 首发症状最高的是:口干58.0%,眼干54.0%,关节肿痛53.0%;实验室检查:异常人数超过50.0%的包括:高γ-球蛋白血症(91.0%),唇腺活检(90.0%),唾液腺流量降低(75.0%),ESR增快(63.0%)。结论 医师发现患者有口干、眼干、关节肿痛等症状≥1项时,就应检查γ-球蛋白,若升高则应进行唇腺活检或唾液流量检查,以减少pSS的漏诊和误诊。 【关键词】 原发性干燥综合征;首发症状;口干;眼干;关节肿痛;高γ球蛋白血症 Clinical initialdose happen symptom and laboratory examination of 100 cases analyse of PSS ZHANG Hong-yi,HU Xiu-qin,JIN Zhong-pin.Binzhou Bin City Bin City Sanhe Town Center Hospital,of Binzhou Bin City Shandong Zouping, Shandong 256200 China 【Abstract】 Objective The To know Primary Sjogrens syndrome(pSS) of Clinical initialdose happen symptom and laboratory examination evidence characteristic,and to raise vs PSS of gnosia level,with use decrease misdiagnosis missed diagnosis.Methods Conducted retrospective analysis The vs 100 case pSS of clinical data progression retrospective analysis.Results The initialdose happen symptom supreme beincluded:58.0% of dry mouth, 54.0% of eye drying, 53.0% of joint gall;Laboratory examination:abnormality case load exceed 50.0% includedhave:The high γ-globulinemia illness is (91.0%), the labial gland biopsy is (90.0%), the salivary gland flow rate debase is (75.0%), 63.0% of ESR expedite(63.0%).Conclusion The doctor find patient who have dry mouth,eye drying,or the joint gall which and all symptom ≥ 1 nape moment, theythe with should take examining γ-globulin, the as ifIf the examining result is elevation ,follow should progression labial glands biopsy orand salivary gland flow rate should be examed., use It will decreas pSS of missed diagnosis and misdiagnosis rate of. pSS. 【Key words】 Primary Sjogren’s syndrome; Nitialdose happen symptom; Dry mouth; Eye drying; Joint gall; High γ-globulinemia illness 作者单位:256653滨州市滨城区三河湖镇中心卫生院(张洪义 胡秀芹);滨州职业学院(金仲品) 通迅作者:金仲品 原发性干燥综合征(primary Sjogrens syndrome,pSS)是以口、眼干燥、关节肿痛为常见表现的一种全身性自身免疫性疾病,常呈现家族聚集性[1]。表现为淋巴细胞和浆细胞对靶器官的进行性浸润,导致靶器官功能障碍,除波及大唾液腺、