浅论甲钴胺片处方优选（Discussion on the optimization of the formulation of Mecobalamin Tablets）.docVIP

浅论甲钴胺片处方优选（Discussion on the optimization of the formulation of Mecobalamin Tablets） Discussion on the optimization of the formulation of Mecobalamin Tablets Date: 07, 10 Abstract: Mecobalamin Tablets; prescription; orthogonal design test; dissolution Objective to screen the best prescription composition [Mecobalamin Tablets. Methods: microcrystalline cellulose (MCC), excipients in twelve sodium dodecyl sulfate (SDS-Na), sodium carboxymethyl starch (CMS-Na), silica gel (SiliciiDoxydum) as investigation factors, each factor three levels, L9 (34) orthogonal test table layout, with Mecobalamin Tabletss dissolution as the main index the tablet weight difference as reference index, orthogonal test was 1. The influence of Mecobalamin Tablets stripping the main influencing factors of twelve sodium dodecyl sulfate adjuvant, the best prescription for the composition of microcrystalline cellulose (PH101) 35g, twelve sodium dodecyl sulfate 4.0g, sodium carboxymethyl starch 1.5g, silica powder 1.5g. Conclusion the formulation and preparation of the Mecobalamin Tablets dissolution is higher, and the product quality is stable, the preparation process is simple and feasible, suitable for industrial production. [Mecobalamin Tablets; prescription; orthogonal design test; dissolution Study, on, formulation, and, preparation, technique, of, Mecobalamin, tablets Abstract Objective To select the [optimum formulation technique of mecobalamin tablets. Methods The L9 (34) orthogonal table and four factors (dissolution as main factor, weight difference as reference factor were to select the) used best formulation by taking MCC (HP101), SDS-Na, CMS-Na and silicii doxydum as the four factors, and three levels were adopted for each factors. Results The experimental resultes indicated SDS-Na was the chief factor of influencing dissolution of macobalamin tablets. The optimum formulation was composed of MCC (HP101) 35g, SDS-Na 4.0g, CMS-Na 1.5g and silicii doxydum 1.5g. Conclusion The optimum for