石墨烯衍生物在肿瘤治疗方面的研究进展 - 新型炭材料.pdf

第28卷摇 第5期 新摇 型摇 炭摇 材摇 料 Vol.28摇 No.5 摇 2013年 10月 NEW CARBON MATERIALS Oct. 2013 摇 文章编号:摇 1007鄄8827(2013)05鄄0321鄄06 石墨烯衍生物在肿瘤治疗方面的研究进展 王晓敏,摇 张伟花 (太原理工大学 材料科学与工程学院,山西 太原 030024) 摘摇 要:摇 石墨烯衍生物是利用氧化石墨烯表面的含氧官能团进行化学修饰而形成的复合炭材料。 在兼备石墨烯非凡的物理及 化学性质基础上,石墨烯衍生物还具有优良的水溶性和生物相容性,从而拓展了石墨烯的应用领域。 综述石墨烯衍生物在肿瘤 治疗方面的研究进展,主要包括生物成像、纳米载药及光动力疗法,为其在生物医药领域的进一步应用提供了新方法和新思路。 关键词:摇 石墨烯衍生物;肿瘤治疗;光动力;药物载体 中图分类号:摇 R331摇 R73鄄3 文献标识码:摇 A 收稿日期:2013鄄05鄄23;摇 修回日期:2013鄄09鄄25 基金项目:国家自然科学基金51242007);山西省自然科学基金(20100011033鄄2). 作者简介:王晓敏,教授.Tel/ Fax:0351鄄6010768;E鄄mail:wangxiaomin@tyut.edu.cn Application of graphene derivatives in cancer therapy:a review WANG Xiao鄄min,摇 ZHANG Wei鄄hua (College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China) Abstract:摇 Graphene derivativesgeneratedby modifying the surface oxygen functional groups of graphene oxide have been widely investigated in recent years. Graphene derivativespossessexcellent aqueous solubility andbiocompatibility similar to graphene oxide, which are important in their biomedical application. Research progresson theuse of graphene derivativesinbiological imaging,drug carriersandphotodynamic therapy of cancer ispresented. Future efforts to improve their performance in cancer therapy are also pro鄄 posed,such asloweringthe toxic effects introduced by chemicals used in the preparation of the graphene derivatives,expanding the drugtoinclude genesandproteins,and couplingphotodynamic therapy with imaging. Keywords:摇 Graphene derivatives;Cancer therapy;Photodynamic;Drug carriers Foundation item:National Natural Science Foundation of China 51242007);Natural Foundation of Shanxi Province (201000110