淋巴化疗在食管癌治疗中的应用现状.PDF

中国胸心血管外科临床杂志 2017 年8 月第24 卷第8 期 • 1 •   ·综　　述· 淋巴化疗在食管癌治疗中的应用现状 蔡杰，倪彭智，王文凭，郑希，陈龙奇 四川大学华西医院 胸外科（成都  610041 ） 【摘要】   淋巴转移是食管癌转移扩散的主要渠道之一，是影响食管癌患者预后最关键的因素之一。局部化 疗相较于全身给药，对正常组织的毒性作用、系统性的副作用影响更小。纳米炭是目前术中淋巴化疗最常用安全 有效的载体。在许多肿瘤淋巴化疗中，纳米炭起到很好的示踪和靶向作用。淋巴化疗应用于肿瘤的治疗之中，可 诱导肿瘤变性坏死、促进肿瘤凋亡。在食管癌治疗中，活性炭靶向淋巴化疗可提高淋巴清扫数目及转移检出率， 减小肿瘤体积，提高患者的生存质量和生存率。淋巴化疗可以作为一种辅助治疗，杀伤在淋巴结中的肿瘤细胞及 微转移癌灶。本文就食管癌转移特点、纳米炭载体淋巴化疗的意义、机制以及临床应用予以讨论。 【关键词】  淋巴化疗；食管癌；纳米碳 Current Situation of Lymphatic Chemotherapy in Esophageal Cancer CAI Jie, NI Pengzhi, WANG Wenping, ZHENG Xi, CHEN Longqi Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R.China Corresponding author: CHEN Longqi, Email: drchenlq@scu.edu.cn 【Abstract 】 Lymphatic metastasis of esophageal cancer is one of the main ways of esophageal cancer metastasis and it is as well one of the most important factors influencing the prognosis of esophageal cancer patients. Compared to intravenous administration of chemotherapy, local chemotherapy has the less toxicity and less systemic side effects. Nano carbon is a safe and effective carrier for intraoperative lymphatic chemotherapy. It plays an important role in tracing and targeting lymph node during the lymphatic chemotherapy. Lymphatic chemotherapy can induce tumor into necrosis and apoptosis. For esophageal cancer, lymphatic chemotherapy is also to be proved to improve the rate of lymph node dissection and the number of metastatic lymph nodes, decrease tumor size, improve the quality of life and survival rate. In conclusion, lymphatic chemotherapy can be considered an assistant therapy to eliminate the tumor cell in lymph nodes and micrometastatic foci. In this review, the metastatic characteristic of esophageal ca