乙肝患者HBV-DNA含量及性别、年龄关系探究.doc

乙肝患者HBV-DNA含量及性别、年龄关系探究[摘要] 目的：探讨不同性别及年龄段乙肝患者HBV-DNA含量的变化规律。方法：选择经ELISA检测为HBsAg阳性携带者血清465例，采用荧光定量聚合酶链反应（FQ-PCR）技术测定血清HBV-DNA含量，并根据不同性别及年龄段HBV-DNA含量进行相关性分析。结果：465例HBsAg阳性标本中，所检测的乙肝患者HBV-DNA含量随年龄增长逐渐下降。30岁以前男性患者HBV-DNA含量比女性患者高，而31岁以后女性患者HBV-DNA含量较男性患者较高；HBV-DNA平均含量男性患者大于女性患者。结论：HBV-DNA含量与年龄呈负相关；HBV-DNA含量男性明显高于女性；乙肝患者应做HBV-DNA检测，有助于HBV感染者传染性大小的判断以及对抗病毒药物临床疗效的评价，以确定最佳治疗方案。 [关键词] 乙型肝炎病毒；性别；年龄；荧光定量聚合酶链反应 [中图分类号]R512.6+2 [文献标识码] B[文章编号] 1673-7210（2009）02（b）-121-02 Research on the relationship between HBV-DNA content and sex as well as age in hepatitis B patients HU Ji-mei1, ZHANG Dong-wu1, ZENG Jun-rong1, ZHENG Ding-rong2 (1.Clinical Laboratory, Conghua Central Hospital of Guangdong Province, Conghua 510900, China; 2.Xixiang People’s Hospital, Bao’an District of Shenzhen, Guangdong Province, Shenzhen 518102, China) [Abstract] Objective: To discuss the change law of HBV-DNA content in hepatitis B patients with different sex and age. Methods: The serum HBV-DNA content of 465 cases of HBsAg positive carriers confirmed by ELISA method was determined by fluorescence quota polymerase chain reaction (FQ-PCR), and the correlation analysis was performed according to the HBV-DNA content of different sex and ages. Results: In 465 cases of HbsAg positive specimen, the HBV-DNA content of hepatitis B patients decreased gradually along with the growth of age; the HBV-DNA content in males was higher than that in females before 30 years old, but the HBV-DNA content in females was higher than that in males after 31 years old. Male patients showed a higher average HBV-DNA content than that in female patient. Conclusion: HBV-DNA content shows a negative correlation with age, and males show a higher HBV-DNA content than that in females. HBV-DNA detection is contribute to the judgment of infectiousness of HBV infected individuals and the evaluation of clinical effect of anti-virus drugs and further to decide the best therapeutic scheme. [Key words] Hepatitis B virus; Sex; A