卡泊三醇软膏联合复方丙酸氯倍他索软膏治疗斑块状银屑病疗效观察.docVIP

卡泊三醇软膏联合复方丙酸氯倍他索软膏治疗斑块状银屑病疗效观察[摘要]目的 观察卡泊三醇软膏及复方丙酸氯倍他索软膏治疗斑块状银屑病的疗效及安全性。方法 选择门诊斑块状寻常型银屑病患者96例，随机分治疗组及对照组各48例，治疗组每日卡泊三醇软膏及复方丙酸氯倍他索软膏早晚交替使用；对照组每日卡泊三醇乳膏及卤米松乳膏早晚交替使用，治疗前及治疗后第2、4、8周观察皮损面积及严重度指数（PASI评分）判定疗效指数，根据不良反应判定其安全性。结果 经过8周观察，治疗组有效率95.8%，对照组有效率81.3%。治疗组3例出现不良反应，对照组6例出现不良反应，症状轻微，患者均可耐受。结论 卡泊三醇和复方丙酸氯倍他索交替使用治疗斑块状银屑病见效快，不良反应轻微，可作为外用药联合使用选择方案之一。 [关键词] 寻常型银屑病；斑块状；卡泊三醇软膏；复方丙酸氯倍他索软膏 [中图分类号] R758.63 [文献标识码] B [文章编号] 1673-9701（2011）32-62-02 The Treatment Efficacy of Plaque Type Psoriasis Vulgaris Using Calcipotriol Cream Combined with Compound Clobetasol Propionate Ointment LI Mingxin LI Bo Dalian Dermatosis Hospital , Dalian116021, China [Abstact] Objective To observe the efficacy and safety of treatment in plaque type psoriasis vulgaris using calcipotriol cream combined with compound clobetasol propionate ointment. Methods There were 96 patients of plaque type psoriasis vulgaris and were randomly divided into two groups: treatment group used calcipotriol cream combined with compound clobetasol propionate ointment sequentially, control group used calcipotriol cream combined with halometasone cream sequentially. The PASI scores were evaluated at the beginning of treatment and at week 2, 4 and 8 after the initiation. Results After 8 weeks treatment, the efficacy of treatment group was 95.8%, and 81.3% in control group. The incidence of adverse reactions in treatment group was less than that in control group. Conclusion There are advantages of treatment in plaque type psoriasis vulgaris using calcipotriol cream combined with compound clobetasol propionate ointment : rapid and good response, as well as less adverse reactions. [Key words] Psoriasis vulgaris ；Plaque type ；Calcipotriol cream ；Compound clobetasol propionate ointment 寻常型银屑病是一种常见的慢性复发性炎症性皮肤病，临床上皮损反复发作后易形成暗红色肥厚性斑块，经久不退，严重影响患者的生活质量。治疗常外用糖皮质激素、维甲酸类、卡泊三醇等药物。笔者采用卡泊三醇软膏及复方丙酸氯倍他索软膏交替使用治疗斑块状银屑病96例，效果明显，现报道如下。 1#8195;资料与方法 1.1 一般资料 96例患者均为我院门诊 2008年4月～2009年12月所收治 ，男女不限，根据《中国临床皮肤病学》诊断寻常型银屑病，皮损呈斑