奥曲肽治疗急性水肿型胰腺炎疗效研究.doc

奥曲肽治疗急性水肿型胰腺炎疗效研究[摘要] 目的:对奥曲肽在急性水肿型胰腺炎治疗中的疗效进行评价。方法:对我院2007～2008年25例急性水肿型胰腺炎患者进行分析,其中,17 例应用先缓慢静脉推注奥曲肽100 μg 后,继以每小时25 μg 的速度持续静滴,连用3 d,其余8 例为对照组。结果:治疗组腹痛缓解时间及恢复进食时间均较对照组显著缩短, 两组血淀粉酶及血象恢复时间无显著性差异。结论:奥曲肽治疗急性水肿型胰腺炎有一定的疗效,对于经济条件允许的患者,在治疗中可加用奥曲肽。 [关键词] 奥曲肽;急性水肿型胰腺炎;疗效 [中图分类号] R657.5[文献标识码]A [文章编号]1673-7210(2009)08(b)-060-02 Therapeutic evaluation of Octreotide in acute edematous pancreatitis ZHANG Yun1, LU Yu2 (1.The First Physician Area, Shenyang Yimin Hospital, Shenyang 110122, China; 2.Medical Affairs, the 4th Affiliated Hospital of China Medical University, Shenyang 110032, China) [Abstract] Objective: To investigate the efficacy of Octreotide in acute edematous pancreatitis. Methods: We reviewed the clinical data of 25 cases of acute edematous pancreatitis admitted during the past two years(2007-2008). 17 cases received 100 μg Octreotide by vein push and persistant venous transfusion in velocity 25 μg per hour for 3 days, and the other 8 cases comprised the control group. Results: A significant difference was observed in toleratedoral intake time and the duration of pain between the two groups. There was no significant difference in the recovery of serum amylase and leucocytes. Conclusion: Octreotide treatment of acute edematous pancreatitis has a certain effect, to allow for the economic conditions of patients in the treatment of Octreotide may be used. [Key words] Octreotide; Acute edematous pancreatitis; Therapeutic effectiveness 奥曲肽为人工合成的生长抑素八肽衍生物,同天然生长抑素十四肽相比,具有血浆半衰期长、作用更强大等特点[1],已广泛应用于急性出血坏死型胰腺炎的治疗,并取得了肯定的疗效,可以减少并发症、提高治愈率[2]。但对于其在急性水肿型胰腺炎治疗中的应用则存在争议。本研究旨在对奥曲肽在急性水肿型胰腺炎治疗中的疗效进行讨论。 1 资料与方法 1.1 一般资料 对我院2007～2008年2年内的急性水肿型胰腺炎住院病例进行回顾性研究,共25例,根据临床表现及实验室检查均确诊为急性水肿型胰腺炎,无并发症发生,男19例,女6例;年龄22～75岁;其中,应用奥曲肽者17例为治疗组,其余8例为对照组。两组一般资料具有可比性。 1.2 治疗方法 治疗组应用瑞士诺华制药公司生产的善得定针(奥曲肽注射液)。先缓慢静脉推注奥曲肽100 μg后,继以每小时25 μg的速度持续静滴,共3 d,同时予禁食、胃肠减压、补液、奥美拉唑、山莨菪碱及抗生素治疗。对照组除未用奥曲肽外,其余治疗均与治疗组相同。 1.3 评价指标 观察两组患者的腹痛缓解时间、恢复进食时间、血淀粉酶恢复正常时间及血象恢复正常时间,并进行比较分析。