宫颈疾病治疗中人表皮生长因子(金因肽)应用探究.doc

宫颈疾病治疗中人表皮生长因子(金因肽)应用探究[摘要] 目的 研究宫颈疾病经高频电波刀(HFLEEP)治疗后喷涂外用重组人表皮生长因子 (rhEGF,金因肽)的临床疗效。方法 选择宫颈疾病需治疗患者,宫颈柱状上皮异位、宫颈息肉、宫颈腺囊肿采用LEEP电凝(COAG)治疗; CIN患者行宫颈环形电切(LEEP)术。研究组180例术毕创面喷涂金因肽;对照组180例术后不采取辅助处理。术后每周复查,记录创面完全愈合时间、阴道流血时间、阴道排液时间。结果 术后4周比较两组指标有显著性差异(P0.05)。结论 宫颈疾病经高频电波刀治疗后喷涂金因肽,可缩短创面完全愈合时间、阴道流血时间、阴道排液时间。 [关键词] 宫颈柱状上皮异位;宫颈息肉;宫颈腺体囊肿;CIN;高频电波刀;外用重组人表皮生长因子(rhEGF,金因肽) [中图分类号] R711.74 [文献标识码] A[文章编号] 1673-9701(2010)02-42-03 Application of Recombinant Human Epidermal Growth Factor in Cervical Diseases YU WenjieMO PanyanZHONG Xiaoye Department of Gynecology,Qingyuan City Maternal and Child Health Hospital,Qingyuan 511500,China [Abstract] Objective To investigate the clinical effect of external use of recombinant human epidermal growth factor(rhEGF) at its wound after cervical disease was treated by high frequency loop electrosurgical excision procedure(LEEP). Methods The patients who needed to be treated due to cervical disease were divided into study group(180 cases) and control group(180 cases). Cervical ectopic columnar epithelium, cervical polyps and cervical gland cyst were treated by using LEEP electrocoagulation(COAG) and the patients with cervical intraepithelial neoplasia(CIN)were treated by LEEP. The rhEGF spray(Gene Time) was applied to the wound after LEEP in the 180 cases of the study group,and the 180 cases of the control group were treated by only LEEP without any auxiliary treatment. The wound healing time,vaginal bleeding time and vaginal discharge time after surgery were recorded. Results The comparison of the indicators at 4 weeks after surgery showed a significant difference between the two groups(P 1.2.2操作方法选择月经干净3～7d内进行。术时患者取膀胱截石位,常规消毒外阴阴道,窥阴器充分暴露子宫颈,拭净阴道内宫颈分泌物,常规消毒。宫颈柱状上皮异位、宫颈息肉、宫颈腺囊肿采用LEEP电凝方法:调功率20～40W,用针状电极或球状电极电凝病变组织,宽度超过病变区外缘2mm,深度≤3mm,至创面呈淡黄色,无渗血;CIN患者采用LEEP环形电切方法:调功率50～80W,用环形电极环形切除病变组织,切割宽度超过病变区外缘0.5cm,深度1.5～2.5cm,滚球电极电灼切割面至焦黄色,无活动性出血。术后两组患者禁剧烈运动2周,禁性生活及盆浴2个月。每周随访,共8周。 对照组单纯使用上述LEEP术治疗。研究组在对照组方法基础上,术毕于宫颈全部创面包括边缘,喷涂重组人表