心衰急性期血清中脑利钠肽及hs-CRP表达.doc

心衰急性期血清中脑利钠肽及hs-CRP表达[摘要] 目的 检测脑利钠肽（BNP）和超敏C反应蛋白（hs-CRP）在慢性心力衰竭患者血清中的表达，探讨其临床意义。 方法 选取我院诊治的98例慢性心力衰竭的患者作为观察组，选取体检为正常成人60例血清作为对照组，检测两组血清中BNP和hs-CRP的含量，探讨其临床意义。 结果 观察组血清中BNP和hs-CRP的表达量显著高于对照组，BNP和hs-CRP的表达与慢性心力衰竭的分级密切相关，经线性相关分析显示观察组患者血清中BNP和hs-CRP的表达呈正相关性。 结论 BNP和hs-CRP在慢性心力衰竭患者血清中高表达，二者的协同作用在疾病的发展中具有重要促进作用，BNP和hs-CRP的联合检测对判断慢性心力衰竭的严重程度及指导治疗可能具有重要作用。 [关键词] 心力衰竭；脑利钠肽；超敏C反应蛋白；临床意义；酶联免疫吸附实验 [中图分类号] R541.6 [文献标识码] B [文章编号] 1673-9701（2011）35-40-02 The Expressions of BNP and hs-CRP in Acute Stage Patients with Chronic Heart Failure HONG Liming ZHAN Yixing PAN Ximing Department of Emergency， Suichang County Peoples Hospital of Zhejiang Province，Suichang 323300，China [Abstract] Objective To detect the expressions of BNP and hs-CRP in acute stage patients with chronic heart failure，to investigage their clinical significance. Methods All of 98 cases chronic heart failure as observation group and 60 cases normal serum as control group，and to detect the expressions of BNP and hs-CRP in different clinical characters. Results The expressions of BNP and hs-CRP were higher in the observation group than the control group. Compared with the control group，the expressions of BNP and hs-CRP were correlated with patients grade. There was positive correlationship between BNP and hs-CRP in patients. Conclusion The higher expressions of BNP and hs-CRP may promote the occurrence and development in chronic heart failure. The joint detection of BNP and hs-CRP should be helpful to predict the severity in patients with chronic heart failure. [Key words] Heart failure；BNP；hs-CRP；Clinical significance；ELISA 慢性心力衰竭是由于心肌梗死、心肌纤维化、心肌冬眠、心肌硬化等所引起，临床主要表现为进行性心肌肥大、心功能减退、心律失常及猝死等，疾病发展过程中，血清中相关细胞因子会有明显改变。脑利钠肽（BNP）是心肌细胞分泌的一种激素，具有拮抗神经内分泌系统的激活，扩张血管和利钠利尿的作用[1-2]。超敏C反应蛋白（hs-CRP）是人类肝细胞合成的急性时相蛋白，当机体受到炎症感染或组织损伤时，其在外周血中的表达增高[3]。本实验关注慢性心力衰竭患者血清中脑利钠肽（BNP）和hs-CRP的检测情况，探讨其临床价值，旨在为慢性心力衰竭诊断及治疗提供帮助。 1 资料与方法 1.1 一般资料 选取2008年1月～2010年12月在我院确诊为慢性心力衰竭的患者，纳入标准：①符合Framinham关于慢性心力衰竭的诊断标准[4]；②临床资料完整。排除