急、慢性荨麻疹及丘疹性荨麻疹患者血清过敏原特异性IgE检测研究.doc

急、慢性荨麻疹及丘疹性荨麻疹患者血清过敏原特异性IgE检测研究[摘要] 目的:研究徐州及周边地区荨麻疹、丘疹性荨麻疹的发生与过敏原之间的关系。方法:采用过敏原特异性IgE抗体检测试剂盒(ELISA法)对586例吸入组及食物组急、慢性荨麻疹及丘疹性荨麻疹患者血清进行过敏原特异性IgE抗体检测。结果:所有病例总IgE均阳性,72.70%(426/586)的患者检测到过敏原,其中257例(43.86%)患者对2项或2项以上过敏原过敏;在所检测的特异性过敏原项目中,急、慢性荨麻疹检测阳性率及过敏强弱无显著性差异。丘疹性荨麻疹过敏原主要为螨虫、蟑螂、蚊子。结论:徐州及周边地区荨麻疹、丘疹性荨麻疹的发生与过敏原之间关系密切;荨麻疹、丘疹性荨麻疹患者血清过敏原特异性IgE抗体检测能帮助临床医师作出病因诊断,指导患者正确防治。 [关键词] 荨麻疹;丘疹性荨麻疹;过敏原;特异性IgE抗体 [中图分类号] R758.24[文献标识码]A [文章编号]1673-7210(2009)08(a)-018-03 Analysis of serum allergen-specific IgE in urticaria and urticaria papulosa patients MA Haijun, WEI Zhiping (Department of Dermatology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China) [Abstract] Objective: To investigate the relationship between allergens and the causes of urticaria in Xuzhou and adjacent districts. Methods: The serum specific ingestive and inhalant allergens of 586 cases of urticaria and urticaria papulosa patients were detected by allergen in vitro test kit (ELISA). Results: Total IgE was detected in all patients, 72.70% (426/586) patients showed positive reaction to at least one of the allergens, and 257 (43.86%) patients showed positive reaction to two or more than two allergens. Positive cases of the allergen-specific IgE was showed no significant difference between the acute urticaria and chronic urticaria. The majority allergens of urticaria papulosa were mites, cockroaches and mosquitoes. Conclusion: The occurrence of urticaria and urticaria papulosa in Xuzhou and adjacent districts is closely related to allergens. The detection of serum allergen-specific IgE antibody of patients with urticaria papulosa can help doctors make diagnosis and guide patients to receive correct prevention and treatment. [Key words] Urticaria; Urticaria papulosa; Allergens; Allergen-specific IgE 荨麻疹是一种常见的皮肤黏膜变应性皮肤病[1],病因较为复杂,按病程分为急性荨麻疹和慢性荨麻疹2种;丘疹性荨麻疹主要见于儿童,为与节肢动物叮咬有关的过敏性皮肤病。为评价过敏原特异性IgE抗体检测在荨麻疹及丘疹性荨麻疹诊治中的价值,我科2008年6月～2009年2月对586例吸入组及食物组急、慢性荨麻疹及丘疹性荨麻疹患者血清进行过敏原特异性IgE抗体检测,并进行了分析,