糖化血红蛋白在脑梗死中临床应用研究.docVIP

糖化血红蛋白在脑梗死中临床应用研究（1.亳州市人民医院检验科，安徽亳州223500； 2.亳州市疾病控制中心检验科，安徽亳州223500） [摘要] 目的 探讨糖化血红蛋白（HbA1c）检测在脑梗死中的临床应用价值。 方法将315例脑梗死患者分为两组：对照组和高糖化血红蛋白组，采用离子交换液相色谱法测定糖化血红蛋白值。结果高糖化血红蛋白组较对照组在发生脑梗死时，病情更为严重，预后较差，病灶较大，死亡率较高（P＜0.05）。结论 脑梗死病情严重程度与糖化血红蛋白水平呈正相关，可以将糖化血红蛋白水平作为脑梗死病情判断、预后以及脑梗死预防的重要指标之一，这对于脑梗死在预防、治疗上有着重要的临床意义。 [关键词] 糖化血红蛋白；脑梗死；严重程度；预后 [中图分类号]R587.2 [文献标识码] B[文章编号]1673-9701（2011）25-107-02 Clinical Application of Glycosylated Hemoglobin in Cerebral Infarction AO Jiafu1WANG Xiangying2SHI Xiufang1 1.Department of Laboratory,Bozhou City People’s Hospital, Bozhou 223500, China;2. Department of Laboratory,Centers for Disease Control of Bozhou City, Bozhou 223500, China [Abstract] Objective To investigate the glycosylated hemoglobin ( HbA1c) detection in the diagnosis of cerebral infarction clinical application value. Methods Three hundreds and fifteencases of cerebral infarction were divided into two groups: control group, high HbA1c group, using the ion exchange liquid chromatography method for the determination of glycosylated hemoglobin values. Results High HbA1c group than in the control group （P＜0.05) in cerebral infarction, the condition was more serious, the prognosis was worse, larger lesions, the mortality rate was higher. Conclusion The cerebral infarction severity of illness and HbA1c levels arepositively correlated to HbA1c levels as cerebral infarction evaluation and prognosis and prevention of cerebral infarct is one of the important indexes, which in the prevention and treatment for cerebral infarction has important clinical significance. [Key words] Glycosylated hemoglobin ; Cerebral infarction; Severity; Prognosis 众所周知糖化血红蛋白是反映被检测者测定前1～2个月平均的血糖水平。所以， HbAlc可以作为判定脑梗死时血糖升高为应激性升高还是糖尿病导致的长期升高。在糖尿病合并脑梗死时，HbAlc水平明显高于正常人群水平。根据近年来一些学者的研究显示发现，患者在发生脑梗死时的病情严重程度与糖化血红蛋白水平的高低呈正相关[1]。通过对我院315例脑梗死患者进行分析，探讨HbAlc与脑梗死患者病情的关系以及HbAlc在脑梗死的治疗、预后方面的临床应用价值。 1 资料与方法 1.1 一般资料 2010 年11月～2011年4月在我院住院的患者315例。其中，男168 例，女147 例；患者年龄 42～90岁，平均(63.8±1.22）岁。所有病例均为血脂