益心舒胶囊联合比索洛尔对舒张性心衰大鼠的治疗作用.PDF

益心舒胶囊联合比索洛尔对舒张性心衰大鼠的治疗作用  杨兵生，许逸飞，徐青云，陈洁，刘强，毛威(浙江中医药大学附属第一医院，杭州 310006) 摘要：目的 探讨益心舒胶囊联合比索洛尔治疗舒张性心力衰竭心脏血流动力学的影响。方法 采用高盐喂养建立舒张 功能不全性高血压大鼠模型，将 24 只舒张性心力衰竭大鼠随机分为 3 组，分别给予蒸馏水、比索洛尔水溶液、比索洛尔 -益心舒胶囊水溶液治疗，共 6 周，观察左心室压力、左心室充盈时间、左心室舒张末期压力、等容收缩期左心室内压力 上升的最大速率。结果 益心舒联合比索洛尔组大鼠的左心室舒张末期压显著低于对照组和比索洛尔组，但对左心室血 压的影响无统计学差异。益心舒联合比索洛尔组等容收缩期左心室内压力上升的最大速率显著高于对照组(P0.05) ，而等 容舒张期左心室压力下降的最大速率和左心室充盈时间(tdp /dtmax)在 3 组间未见统计学差异。结论 益心舒胶囊联合比 索洛尔可有效改善舒张性心力衰竭大鼠的左心室舒张功能，而不影响左心室血压。 关键词：益心舒胶囊；比索洛尔；舒张性心力衰竭 中图分类号：R994.11 文献标志码：B 文章编号：1007-7693(2016)01-0046-04 DOI: 10.13748/ki.issn1007-7693.2016.01.012 Role of Yixinshu Capsule Combined Bisoprolol Treating Diastolic Heart Failure YANG Bingsheng, XU Yifei, XU Qingyun, CHEN Jie, LIU Qiang, MAO Wei(The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310006, China) ABSTRACT: OBJECTIVE To investigate the role of Yixinshu capsule combined bisoprolol treating diastolic heart failure (DHF) and its impact on cardiac hemodynamics. METHODS High salt feeding built diastolic dysfunction of hypertensive rats. The 24 diastolic heart failure rats were randomly divided into three groups, which were given distilled water, a solution of bisoprolol and a solution of Yixinshu capsule combined bisoprolol treatment for 6 weeks. Then left ventricular pressure, left ventricular filling time, left ventricular end-diastolic pressure, the maximum rate of isovolumic systolic, left ventricular pressure rise(dp /dtmax) were respectively observed. RESULTS Left ventricular end-diastolic pressure of Yixinshu capsule combined bisoprolol was significantly lower than that in the bisoprolol group and the control group(P0.01), but the effect o