经阴道超声引导下卵泡穿刺治疗多囊卵巢综合征不孕临床探究.docVIP

经阴道超声引导下卵泡穿刺治疗多囊卵巢综合征不孕临床探究[摘要] 目的 观察B超引导下经阴道卵泡穿刺微创治疗多囊卵巢综合征（PCOS）合并不孕症患者的临床疗效。 方法将30例PCOS患者，在B超引导下行经阴道卵泡穿刺术。观察其术前、术后的激素水平变化，卵泡数、排卵率、妊娠率及加用克罗米芬后的排卵率。 结果 患者术后各项激素水平均有所变化，排卵率、妊娠率升高，差异有统计学意义（P 0.05）。 结论 超声引导下卵泡穿刺术能改善患者的内分泌状况，提高机体对克罗米芬的敏感性，提高妊娠机会。 [关键词] 多囊卵巢综合征；排卵诱导；激素水平；不孕症 [中图分类号] R713.7 [文献标识码] A [文章编号] 1674-4721（2012）07（c）-0061-02 The clinical research of the polycystic ovary syndrome infertility treatment using follicular puncture guided by the transvaginal ultrasound FENG Wei NIE Ru Dongguan Qingxi Hospital in Guangdong Province, Dongguan 523660, China [Abstract] Objective To observe the clinical curative effect of the follicular puncture treatment guided by transvaginal B ultrasonic for polycystic ovary syndrome(PCOS) with infertility patients. Methods Trirty cases of patients with PCOS were examined, using B ultrasound guidance through vaginal technic of follicles. The preoperative and postoperative hormone level change, follicular number, ovulation rate, the pregnancy rate and the ovulation rate after clomiphene added were observed. Results Firstly, the hormone levels of postoperative changed. Secondly, the ovulation rate and the pregnancy rates increased, and the difference was statistically significant (P 0.05). Conclusion Ultrasound-guided percutaneous follicle can improve the endocrine condition of patients with and improve the sensibility of the body to the the clomiphene, and increase pregnancy opportunity. [Key words] Polycystic ovary syndrome; Ovulation induction; Hormone levels; Infertility 多囊卵巢综合征（polycystic ovary system，PCOS）是女性常见妇科内分泌紊乱性疾病，生育期的患病率为5%～10%，占生育期女性无排卵性不孕的70%[1]，以长期无排卵和高雄激素血症为基本特征。此病影响女性的排卵，是育龄妇女不孕的重要原因。临床常表现为异质性，主要为月经稀发或闭经、多毛、肥胖和不孕。在治疗方面，既往有药物诱导排卵和手术治疗，但疗效和副作用各有利弊。本院采用超声引导下经阴道卵泡穿刺[2-4]合并术后加用克罗米芬（clomiphere citrate，CC）的方法，既能达到较高的排卵率及妊娠率，又能避免以往药物及手术的风险，而且操作简便、价廉，患者容易接受，是一种行之有效且值得推广的治疗方法。 1 资料与方法 1.1 一般资料 2008～2011年在本院确诊的PCOS不孕患者30例，原发不孕20例（66.67%），继发不孕10例（33.33%），年龄22～35岁，不孕时间2～9年，均已用CC治疗3个周期无卵泡发育。男方精液检查结果正常，已排除卵巢早