乳腺癌组织学分级与雌激素受体、孕激素受体、人表皮生长因子受体-2和p53表达及淋巴结转移的相关性.pdfVIP

巾国呈科医学 2c哟年 ㈠新…参第 目期 ·ll7· · 论著 · 乳腺癌组织学分级与雌激素受体、孕激素受体、人表皮生长 因子受体一2和p53表达及淋巴结转移的相关性 冉社伟，王小毅，谭金祥 【摘要】 目的 探讨乳腺癌组织学分级与雌激素受体 (ER)、孕激素受体 (PR)、人表皮生长因子受体一2 (CerBb一2)、p53表达及淋巴结转移的相关性。方法 用免疫组织化学法测定187例乳腺癌组织中ER、PR、CerBb一 2、p53表达；Bloom—Richardson系统Nottingham改良方案测定组织分级。结果 I、Ⅱ、Ⅲ级乳腺癌组织ER、PR、 p53的阳性表达率间差异无显著意义 (P0 05)；随着组织学分级的升高CerBb一2的表达有增加趋势 (P0．05)； ER(+)和PR(+)的乳腺癌组织中CerBb一2(一)和p53(一)表达的比例明显高于CerBb一2(+)和p53 (+)表达 (P0．05)；乳腺癌组织学分级与淋巴结转移间无相关关系(P0．05)。结论 乳腺癌组织q-ER、PR、 p53的表达不随组织学分级的增加而增加；CerBb一2的表达随组织学分级增加而升高；CerBb一2、p53的表达与ER呈 负相关；乳腺癌淋巴结转移与组织学分级无关。 【关键词】 乳腺癌；组织学分级；ER；PR；CerBb一2；p53；淋巴结转移 【中图分类号】R 737．9 【文献标识码】A 【文章编号】1007—9572(2008)lB—O117一O3 Relation of Histological Grade with Expressions of Estrogen Receptor，Progesterone Receptor， CerBb一2 and p53 and Lympha Node Metastasis of Breast Cancer RAN She—wei，WANG Xiao—yi，TAN Jin—xiang，et a1．Department of Surgery of No．7 Hospital of Chongqing，the First Affiliated ttospital of Chongqing University of Medical Sciences．Chongqing 630000． ina 【Abstract】 Objective To investigate the cmTelation between histological grade and expressions of estrogen receptor (ER)，progesterone receptor(PR)，CerBb一2 and p53，and lympha node metastasis of breast cancer．Methods The expres— sions of ER，PR，CerBb一2 and p53 in 187 cases breast cancer were detected by immunohistochemical method：Histological grade were detected by modified Nottingham of Bloom—Richardson system．Results There was no significant difference in posi— tive expression rates of ER，PR and p53 among grade I，II and llI(P0．05)，but the ezpression of CerBb一2 increased with the rise of histological grade(P0．05)．The expressions of CerBb一2(一)and p53(一)were higher than those of CerBb一 2(+)and p53(+)in ER(+)in breast cancer tissue of ER(+)and PR(+)(P0．05)．There was no ob