结节病-图文.pptVIP

Sarcoidosis 王钰翔 定义 病因不明的系统性肉芽肿性疾病 累及全身多系统 病理为非干酪样坏死性上皮细胞肉芽肿 目前病因不明 流行病学 种族、性别、年龄 A Case Controlled Etiologic Study of Sarcoidosis (ACCESS) _ Heterogeneous population ( 53.5 % White, 44.5% Black ) _ Gender (64 %, female, 36%,male) _ Age (46.5 to less than 40 yr and 54.5 to greater than 40 yr) _ Women: greater incidence of eye, neurological , erythema nodosum (EN), over 40 yr _ Men: greater incidence of hypercalcemia _ Black subjects: increased skin involvement (other than EN), eye, liver, and bone marrow involvement, extrathoracic lymph node 临床表现－症状 无症状 12-35 全身症状 15-40 疲劳 20-30