脂联素与子宫肌瘤的相关性研究.pdfVIP

实用预防医学 2008年2月 第15卷 第 1期 Practical Preventive Medicine，Feb 2008，Vol 15，No．1 55 文章编号：1006—3110(2008)01 0055—03 【论 著 】 脂联素与子宫肌瘤的相关性研究 石艳清 ，焦海燕 ，单胜芳 ，吴智清 ，陈 幸 摘要： 目的 探讨脂联素水平与子宫肌瘤发病和生长的相关性。 方法 选100例子宫肌瘤患者为观察组，50例 健康妇女为对照组，测定脂联素(APN)、胰岛素样因子一1(IGF一1)、雌二醇(E2)、孕酮(P)和睾酮(T)。 结果 观察组血 清APN水平为(7．37±2．4)mg／ml，而在健康对照组则为(9．18±3．0)mg／ml，具有显著性差异(P0．05)。多因素分析发 现E2、IGF一1、APN与发病相关。APN和E2负相关 r=0．882)；APN和 IGF一1负相关(r=0．773)。多发肌瘤组(7．19 ±3．89 mg／m1)低于单发肌瘤组APN水平(7．41±2．97 mg／m1)(P0．05)；且随着肌瘤的增大，血清 APN水平逐渐降低。 结论 子宫肌瘤的发病与低水平脂联素可能与子宫肌瘤的发病和肌瘤生长相关，其机制可能通过 IGF一1和雌激素途 径。 关键词： 子宫肌瘤；雌激素；脂联素；胰岛素样因子一1 中图分类号：R737．33 史献标识码：A Study on Correlation of Serum Adiponectin and Uterine Leiomyoma SHI Yan—qing，XIAO Hai—yan，SHAN Sheng一 ng，et a1．(Railway Hospital of Zhangwu County，Zhangwu 123200，Liaoning) Abstract： Objective To explore the correlation between the pathogenesis and growth of uterine leiomyoma and serum adiponectin． Methods Leiomyoma，insulin like growth factor 1(IGF一1)，estradiol(E2)，progesterone and testosterone of 100 patients with uterine leiomyoma(the observed group)and 50 healthy women(the control group)were determined． Results The adiponectin levels of the observed and control groups were 7．37±2．4 and 9．18±3．0 mg／m1．there were sig— nificant differences between the two groups(P0．05)．With multivariate analysis，E2，IGF一1 and APN were associated with the pathogenesis of uterine leiomyoma．APN was inversely related to E2(r=0．882)and IGF一1(r=0．773)．The adi— ponectin level in the multi—myoma group(7．19±3．89 mg／m1)was lower than that of the mono—myoma group(7．41±2．97 mg／m1)，(P0．05)；moreover，with the growth of myoma，the adiponectin level decreased gradually． Conclusions This study suggests that the lower serum adiponectin level might