重组人粒细胞集落刺激因子动员后自体外周血干细胞在大鼠纤维化肝脏内的发育.pdfVIP

中国组织工程研究与临床康复第12 在第3 那 2008 - 01 - 15 出版 Joumal of Clinical Rehabilitative 刀ssue Engineering Research Januaη 15， 2008 协1.12， No.3 @究在安基础运学 重组人粒细胞集落剌激因子动员后自体外周血干细胞在大鼠纤维化 肝脏内的发育食 张智峰，赵钢，赵天宇，朱英 Development of autologous peripheral blood stem cells in the fibrous liver of rats after recombinant human granulocyte colony stimulating factor mobilization Zhang Zhi-feng , Zhao Gang , Zhao Tian-yu , Zhu Ying Abstract AIM: To study the development of autologous peripheral blood stem cells in the fibrous liver after mobilizing recombinant Department of human granulocyte colony stimulating factor and the therapeutical effect of autologous periph巳ral blood stem cell Gastr田nterology， First Affiliat时 transplantation. Hospita l. Dalian 岛IETHODS: Experiments were performed at the Central Laboratory of First Affiliated Hospital , China-Japan Clinical M时ical Univers町， Pathological Center and Central Laboratory of Dalian Medical Univers町仕om April2∞5ωApril2∞6. ①Rat models of Dalian IIω11. hepatic fibrosis were rnade by injecting carbon tetrachloride subcutaneously. Thirty-two suc∞ssfully established rat models Liaoning Provin白， China of hepatic fibrosis were divided into group A , group B , group C and group D with 8 in each group , male and fernale (half and h圳.②Rat models of group A were only adrninistered with recombinant hurnan granuloc如 colony stimulating factor Zhang Zh i-feng. subcutaneously. Rat models of group B were adrninistered with recombinant hurnan granulocyte colony stimulating factor Master