迟发性运动障碍与抗精神病药物治疗关系的研究.PDFVIP

2008 2 1 3 　Jo urna of P sy chiatry, 200 8, Vo 2 1, N o.3 ＊ 1 1 2 1 1 1 李永刚 　谭云龙 　周东丰 　曹连元 　杨甫德 　苏建民 【】　　观察迟发性运动障的发生与长期应用抗精神病药物的关系。　选取北京回龙观医院长期住 院的患者,符合CCMD-3 精神分裂症的诊断标准,抗精神病药剂量恒定维持治疗6 个月。排除器质性疾病及其 它神经精神疾患。先用Simp son 迟发性运动专业量表进行全院患者筛选, 最终选出合乎要求病例 109 例, 再用 A IM S 量表评定, 依据患者用药情况分为三组, 典型抗精神病药组(包括氯丙嗪、奋乃静、氟哌啶醇、安棕酯)、氯氮 平组、利培酮组,使用SP SS 10.0, 采用独立样本t 检验、单因素方差分析, 分析三组药物与T D 的相关性。　 利培酮组的A IM S 总分显著低于典型抗精神病药组(p=0 .032 ),与氯氮平组无显著差异(P =0.275 )。　利 培酮组, 氯氮平组致T D 症状的严重程度偏低, 或对T D 症状有 一定抑制或治疗作用。 【】　迟发性运动障碍　抗精神病药物 【】　R749.6 　【】　A 　　【】　1009-7201(200 8)-03-0165-02 Study of relationship between tardive dyskinesia and antipsychotics.LI Yonggang, TAN Yunlong,ZH OUDong- f eng,et al.Division of Biopsychiatry Research, Beij ing Huilongguan Hosp ital,Beij ing 100096, hina 【Abstract】　Objective 　T o observe the re at ionshi p bet ween t he occurrence of tardive dy ski nesia (T D )and ong-t erm app ication of t reat ments with antip sycho tics.Methods　Lo n-te rm in-pat ient s in Beijing Hui ongg uan H ospit a w ere se ect ed accordi ng with t he diag no sis crit eri a of CCM D-3 f or schizophrenia, w ho se do se of antip- sycho tics had no t been chang ed fo r 6 mont hs.Organic di sease s,o ther neuropat hies and ment a diseases w ere ex- c uded.A t fi rst,a patient s i n the ho spita we re assessed w ith Si mp son Specia Sca e f o r T D and 109 patients were se ected,t hen these patients w ere assessed with A IM S .P atients w ere divided int o three g roup s:c assica ant ipsy cho tic g roup (inc uding ch orprom azi ne, perphenazine, ha operido , pipo tiazine pa mit ate ), c ozapi ne gro up and ri sperido ne g roup .Independent sam p er t-test and one-f act or ana y sis o f variance were u sed in SP SS . Resul ts 　T he t ot a score of A IMS in risperidone g ro up w as significant y ow er than that of c assica g roup (P= 0.032), and had no dif ference w ith c ozap