首发抑郁症局部脑区的功能一致性及其与临床症状的关系.PDFVIP

406 Ch in J N e rv M ent D is V ol. 36, N o. 7 July 2010 首发抑郁症局部脑区的功能一致性及其与 临床症状的关系 * * * * 彭代辉 江开达 方贻儒 徐一峰 刘军 ( M R I) , 16 D SM-IV ( ) 16 , 5 m in12s M R I( HAM D ) , R eH o (P 001) R eH o HAM D ( P 005) , R eH o HAM D ( r= 056, P 005; r= 058, P 005) , R eH o HAM D ( r= 051, P 005) , R eH o HAM D ( r= 05 1, P 005; r= 053, P 005) , R 749. 4 A TheReHo analysis on theassociation of spontaneous regional brain activity with symptoms in first-episodede- pression. PENGDaihui, JIANGK aida, FANG Yiru, X U Yfi eng, LIUJun. ShanghaiM entalH ealth enter, M edicalcollege aff liliated by Shangha iJiaotong Uniw ersity, 600 W anping N an R oad, Shanghai 200030. C h ina. T el: 02 1- Abstract Objective U sing unctiona lm agnetic resonance mi ag ing ( M R I) by resting state, to explore the spon- taneou s activ ity o reg iona l bra in in depressed patien ts and its re lationship w ith the sym ptom s. M ethods S ix teen partici- pants diagnosed w ith m ajor depressive disorde r acco rd ing to D SM- IV and 16 no rm al contro ls w ere scanned during resting sta te or 5 m in and 12 sec. T he seve rity o depression, and unpred icted hom odynam ic responses across the w ho le brain w ere analyzed u sing H am ilton depression sca le ( HAM D ) and hom ogeneity m ethod ( R eH o) , respec tive ly. Results The R eH o o the le t tha lamu s, le t cerebral, occ ipita l lobe and le t temporal lo