beneficial effect of bupleurum polysaccharides on autoimmune-prone mrl-lpr mice柴胡属产生的有利影响多糖在autoimmune-prone mrl-lpr老鼠.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 842928, 11 pages doi:10.1155/2012/842928 Research Article Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice Yi-Wen Jiang,1 Hong Li,1 Yun-Yi Zhang,1 Wen Li,1 Yi-Fan Jiang,1 Ying-Ye Ou,1 and Dao-Feng Chen2 1 Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China 2 Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China Correspondence should be addressed to Hong Li, lxzhang@ and Dao-Feng Chen, dfchen@ Received 4 January 2012; Revised 28 February 2012; Accepted 10 April 2012 Academic Editor: Anne Davidson Copyright © 2012 Yi-Wen Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs. The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium have anticomplementary activity and immunomodulatory functions on macrophages. To study its potential benefit on SLE, we examined effects of BPs on MRL-lpr mice, which have similar disease features to human SLE. MRL-lpr mice were treated orally with BPs 15, 30, or 60 mg kg−1 day−1 for 12 weeks and their SLE characteristics were evaluated. The results revealed that BPs elongated life span, improved kidney function, delayed lymphadenopathy, and reduced autoantibodies. It seemed to be mediated by inhibition of complement and macrophage