control of in vivo transport and toxicity of nanoparticles by tea melanin控制体内的运输和纳米颗粒的毒性茶黑色素.pdfVIP

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2012, Article ID 746960, 11 pages doi:10.1155/2012/746960 Research Article Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin Yu-Shiun Chen,1 Yao-Ching Hung,2, 3 Meng-Yeng Hong,1 Andrei Aleksandrovich Onischuk,4 Jin Chern Chiou,5 Irina V. Sorokina,6 Tatiana Tolstikova,6 and G. Steve Huang1 1 Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan 2 Department of Obstetrics and Gynecology, China Medical University and Hospital, 91 Hsueh Shih Road, Taichung 404, Taiwan 3 College of Medicine, China Medical University, Taichung 40402, Taiwan 4 Institute of Chemical Kinetics Combustion, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia 5 Institute of Electrical Control Engineering, National Chiao Tung University, 1001 University Road, EE772, Hsinchu 300, Taiwan 6 Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia Correspondence should be addressed to G. Steve Huang, gstevehuang@.tw Received 5 April 2012; Accepted 14 May 2012 Academic Editor: Xiaoming Li Copyright © 2012 Yu-Shiun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nanoparticles are unfamiliar to researchers in toxicology. Toxicity may be generated simply due to the reduction in size. Compounds that prevent or cure toxic materials may not work on nanoparticles. Furthermore, as there are more and more applications of nanoparticles in drug delivery and in vivo imaging, cont