diagnostic pitfalls in newborns and babies with blisters and erosions诊断陷阱在新生儿和婴儿水泡和侵蚀.pdfVIP

Hindawi Publishing Corporation Dermatology Research and Practice Volume 2009, Article ID 320403, 10 pages doi:10.1155/2009/320403 Review Article Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions ¨ Elke Nischler, Alfred Klausegger, Clemens Huttner, Gabriele Pohla-Gubo, Anja Diem, Johann W. Bauer, and Helmut Hintner Department of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstraße 48, 5020 Salzburg, Austria Correspondence should be addressed to Elke Nischler, e.nischler@salk.at Received 6 July 2009; Accepted 27 October 2009 Recommended by Clay Cockerell Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis. Copyright © 2009 Elke Nischler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and